ALTERNATIVES TO AROCLOR 1254-INDUCED S9 IN INVITRO GENOTOXICITY ASSAYS

被引：41

作者：

ELLIOTT, BM

COMBES, RD

ELCOMBE, CR

GATEHOUSE, DG

GIBSON, GG

MACKAY, JM

WOLF, RC

机构：

[1] INVERESK RES INT LTD,MUSSELBURGH,SCOTLAND

[2] GLAXO GRP RES LTD,WARE SG12 0DJ,HERTS,ENGLAND

[3] IMPERIAL CANC RES FUND,LONDON WC2A 3PX,ENGLAND

[4] UNIV SURREY,GUILDFORD GU2 5XH,SURREY,ENGLAND

来源：

MUTAGENESIS | 1992年 / 7卷 / 03期

关键词：

D O I：

10.1093/mutage/7.3.175

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A working party was set up by the UK Environmental Mutagen Society to consider alternatives to Aroclor 1254 (Aroclor)-induced S9 in in vitro genotoxicity assays, with the aims of considering whether a replacement for Aroclor in its role in general screening assays could be readily identified. The working party concluded that there was sufficient support in the literature to justify the use of an appropriate phenobarbital/beta-naphthoflavone regime as an acceptable alternative to Aroclor.

引用

页码：175 / 177

页数：3

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