A GENETIC-LOCUS ON PLASMODIUM-FALCIPARUM CHROMOSOME-12 LINKED TO A DEFECT IN MOSQUITO-INFECTIVITY AND MALE GAMETOGENESIS

被引：41

作者：

VAIDYA, AB ^{[1
]}

MURATOVA, O ^{[1
]}

GUINET, F ^{[1
]}

KEISTER, D ^{[1
]}

WELLEMS, TE ^{[1
]}

KASLOW, DC ^{[1
]}

机构：

[1] NIAID,MALARIA RES LAB,BETHESDA,MD

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 1995年 / 69卷 / 01期

关键词：

GENETICS; PLASMODIUM FALCIPARUM; EXFLAGELLATION; GAMETOGENESIS;

D O I：

10.1016/0166-6851(94)00199-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Infection of mosquitoes by Plasmodium spp. requires sexual differentiation of the malarial parasite in the vertebrate host and mating of the heterogametes in the vector midget. A Plasmodium falciparum clone, Dd2, differentiates into normal-appearing gametocytes, yet poorly infects mosquitoes. The Dd2 clone, however, effectively cross-fertilized HB3, a Central American P. falciparum clone, and yielded several independent recombinant progeny. We have examined 11 HB2 X Dd2 progeny for their ability to infect mosquitoes and to differentiate into male gametes. Our analyses indicate that the poor mosquito-infectivity of the Dd2 clone results from a defect in male gametogenesis. This defect was inherited as a single locus in the independent recombinant progeny of HB3 X Dd2. Comparison with a restriction fragment length polymorphism map of the HB2 X Dd2 cross indicates that the defective phenotype of Dd2 maps to a locus on P. falciparum chromosome 12. This genetic locus may contain determinants that play a crucial role in male gametogenesis by P. falciparum.

引用

页码：65 / 71

页数：7

共 20 条

[1]

BAZINET C, 1993, GENETICS, V134, P1119

[2]

Carter R., 1988, MALARIA PRINCIPLES P, P253

[3] UNIPARENTAL INHERITANCE OF THE MITOCHONDRIAL GENE CYTOCHROME-B IN PLASMODIUM-FALCIPARUM [J].