FLUORIDE ION-PROMOTED REACTION OF POLYFLUORO-1-PROPENYL P-TOLUENESULFONATE WITH AMINES - HIGHLY EFFICIENT AND GENERAL ACCESS TO (Z)-ALPHA-FLUORO-BETA-AMINO ACRYLALDEHYDES

被引：18

作者：

FUNABIKI, K

OHTSUKI, T

ISHIHARA, T

YAMANAKA, H

机构：

来源：

CHEMISTRY LETTERS | 1994年 / 06期

关键词：

D O I：

10.1246/cl.1994.1075

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

2,3,3-Trifluoro-1-propenyl p-toluenesulfonate, readily available by dehydrofluorination of 2,2,3,3-tetrafluoropropyl p-toluenesulfonate, reacted smoothly with various primary or secondary amines in the presence of triethylamine and a catalytic amount of fluoride ion at ambient temperature for 3 h or at 70 degrees C for 1-2 h to afford the corresponding (Z)-alpha-fluoro-beta-(alkylamino- or -dialkylamino)acrylaldehydes in good to excellent yields, together with the formation of p-toluenesulfonyl fluoride.

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页码：1075 / 1078

页数：4

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