EFFECTS OF SLEEP ON THE TONIC DRIVE TO RESPIRATORY MUSCLE AND THE THRESHOLD FOR RHYTHM GENERATION IN THE DOG

被引:27
作者
HORNER, RL
KOZAR, LF
KIMOFF, RJ
PHILLIPSON, EA
机构
[1] Department of Medicine, University of Toronto
来源
JOURNAL OF PHYSIOLOGY-LONDON | 1994年 / 474卷 / 03期
关键词
D O I
10.1113/jphysiol.1994.sp020042
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
1. The present study was designed to determine the effect of sleep on the tonic output to respiratory muscle and on the level of chemical respiratory stimulation required to produce rhythmic respiratory output. 2. Chronically implanted electrodes recorded expiratory (triangularis sterni) and inspiratory (diaphragm and parasternal intercostal) electromyographic (EMG) activities in three trained dogs during wakefulness and sleep. The dogs were mechanically hyperventilated via an endotracheal tube inserted into a permanent tracheostomy. During the studies, a cold block of the cervical vagus nerves was maintained to avoid the complicating effects of vagal inputs on respiratory drive and rhythm. 3. During wakefulness, steady-state hypocapnia (partial pressure of CO2, P-CO2 = 30 mmHg) abolished inspiratory EMG activity, resulting in apnoea, but the expiratory muscle became tonically active. Compared to wakefulness, the level of the tonic expiratory EMG activity was decreased in non-REM (non-rapid eye movement) sleep (median decrease = 34%, P = 0.005) and was further decreased in REM deep (median decrease = 78%, P < 0.0001). During REM sleep, the tonic expiratory EMG activity was highly variable (mean coefficient of variation = 39% compared to 7% awake, P < 0.0001) and in some periods of REM, bursts of inspiratory EMG activity and active breathing movements were observed despite the presence of hypocapnia. 4. During constant mechanical hyperventilation, progressive increases in arterial P-CO2 (in hyperoxia) were produced by rebreathing. Measurement of the CO2 threshold for the onset of spontaneous breathing showed that this threshold was not different between wakefulness and non-REM sleep (mean difference = 0.1 mmHg from paired observations, 95% confidence interval for the difference = -1.0 to +1.1 mmHg, P = 0.898). 5. The results show that deep reduces the tonic output to respiratory muscles but does not increase the CO2 threshold for the generation of rhythmic respiratory output. These observations suggest that changes in the tonic drives to the respiratory motoneurones may be a principal mechanism by which changes in sleep-wake states produce changes in respiratory output.
引用
收藏
页码:525 / 537
页数:13
相关论文
共 37 条
  • [1] PHRENIC MOTO-NEURONS IN THE CAT - SUB-POPULATIONS AND NATURE OF RESPIRATORY DRIVE POTENTIALS
    BERGER, AJ
    [J]. JOURNAL OF NEUROPHYSIOLOGY, 1979, 42 (01) : 76 - 90
  • [2] BROWN BW, 1977, STATISTICS BIOMEDICA
  • [3] THE INFLUENCE OF INDUCED HYPOCAPNIA AND SLEEP ON THE ENDOGENOUS RESPIRATORY RHYTHM IN HUMANS
    DATTA, AK
    SHEA, SA
    HORNER, RL
    GUZ, A
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 1991, 440 : 17 - 33
  • [4] TRIANGULARIS STERNI MUSCLE USE IN SUPINE HUMANS
    DETROYER, A
    NINANE, V
    GILMARTIN, JJ
    LEMERRE, C
    ESTENNE, M
    [J]. JOURNAL OF APPLIED PHYSIOLOGY, 1987, 62 (03) : 919 - 925
  • [5] TRIANGULARIS STERNI - A PRIMARY MUSCLE OF BREATHING IN THE DOG
    DETROYER, A
    NINANE, V
    [J]. JOURNAL OF APPLIED PHYSIOLOGY, 1986, 60 (01) : 14 - 21
  • [6] EFFECT OF POSTURE ON EXPIRATORY MUSCLE USE DURING BREATHING IN THE DOG
    DETROYER, A
    NINANE, V
    [J]. RESPIRATION PHYSIOLOGY, 1987, 67 (03): : 311 - 322
  • [7] NEUROGENESIS OF RESPIRATORY RHYTHM AND PATTERN - EMERGING CONCEPTS
    FELDMAN, JL
    SMITH, JC
    ELLENBERGER, HH
    CONNELLY, CA
    LIU, G
    GREER, JJ
    LINDSAY, AD
    OTTO, MR
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 259 (05): : R879 - R886
  • [8] CELLULAR MECHANISMS UNDERLYING MODULATION OF BREATHING PATTERN IN MAMMALS
    FELDMAN, JL
    SMITH, JC
    [J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1989, 563 : 114 - 130
  • [9] FELDMAN JL, 1986, HDB PHYSL 1, V4, P463
  • [10] EFFECT OF DIFFERENTIAL VAGAL COLD BLOCKADE ON BREATHING PATTERN IN CONSCIOUS DOGS
    FISHMAN, NH
    PHILLIPSON, EA
    NADEL, JA
    [J]. JOURNAL OF APPLIED PHYSIOLOGY, 1973, 34 (06) : 754 - 758