EVENT-RELATED POTENTIALS IN PATIENTS WITH CEREBELLAR DEGENERATION - ELECTROPHYSIOLOGICAL EVIDENCE FOR COGNITIVE IMPAIRMENT

被引:18
作者
TACHIBANA, H
ARAGANE, K
SUGITA, M
机构
[1] Fifth Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, 663
来源
COGNITIVE BRAIN RESEARCH | 1995年 / 2卷 / 03期
关键词
EVENT-RELATED POTENTIAL; NA; N2; P3; CEREBELLAR ATROPHY; COGNITION;
D O I
10.1016/0926-6410(95)90006-3
中图分类号
TP18 [人工智能理论];
学科分类号
081104 ; 0812 ; 0835 ; 1405 ;
摘要
We measured event-related potentials and reaction times during semantic discrimination tasks in 8 patients with cerebellar degeneration and in 10 normal subjects. The NA, N2 and P3 latencies of patients were significantly longer in patients, whereas N1 and P2 latencies did not differ between both groups. There was also no difference in the simple and GO/NOGO reaction times. These results suggest that these patients' impairment in cognitive information processing arose from a difficulty in pattern recognition of the stimuli represented by the NA component. These data also support the notion that the cerebellum plays a role in cognitive information processing.
引用
收藏
页码:173 / 180
页数:8
相关论文
共 35 条
[1]  
Appollonio, Grafmann, Schwartz, Massaquoi, Hallett, Memory in patients with cerebellar degeneration, Neurology, 43, pp. 1536-1544, (1993)
[2]  
Chayasirisobhon, Brinkman, Gerganoff, Gershon, Pomara, Green, Event-related potential in Alzheimer disease, Clin. Electroencephalogr., 16, pp. 48-53, (1985)
[3]  
Fiez, Petersen, Cheney, Raichle, Impaired non-motor learning and error detection associated with cerebellar damage, Brain, 115, pp. 155-178, (1992)
[4]  
Folstein, Folstein, McHugh, “Mini-Mental State”. A practical method for grading the cognitive stage of patients for the clinician, J. Psychiatr. Res., 12, pp. 189-198, (1975)
[5]  
Goodin, Aminoff, Evaluation of dementia by event-related potentials, J. Clin. Neurophysiol., 9, pp. 521-525, (1992)
[6]  
Grafman, Litvan, Massaquoi, Stewart, Sirigu, Hallett, Cognitive planning deficit in patients with cerebellar atrophy, Neurology, 42, pp. 1493-1496, (1992)
[7]  
Hasegawa, The clinical assessment of dementia in the aged: a dementia screening scale for psychogeriatric patients, Aging in the Eighties and Beyond, pp. 207-218, (1983)
[8]  
Inhoff, Diener, Rafal, Ivry, The role of cerebullar structures in the execution of serial movements, Brain, 112, pp. 565-581, (1989)
[9]  
Ivry, Diener, Impaired velocity perception in patients with lesions of the cerebellum, J. Cogn. Neurosci., 3, pp. 355-366, (1991)
[10]  
Ivry, Keele, Timing functions of the cerebellum, J. Cogn. Neurosci., 1, pp. 136-152, (1989)