COANTIOXIDANTS MAKE ALPHA-TOCOPHEROL AN EFFICIENT ANTIOXIDANT FOR LOW-DENSITY-LIPOPROTEIN

被引：105

作者：

THOMAS, SR ^{[1
]}

NEUZIL, J ^{[1
]}

MOHR, D ^{[1
]}

STOCKER, R ^{[1
]}

机构：

[1] HEART RES INST, BIOCHEM GRP, CAMPERDOWN, NSW, AUSTRALIA

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 1995年 / 62卷 / 06期

关键词：

ANTIOXIDANTS; ASCORBATE; ATHEROSCLEROSIS; BILIRUBIN; 3-HYDROXYANTHRANILIC ACID; LIPID PEROXIDATION; ALPHA-TOCOPHEROL RADICAL; UBIQUINOL-10; VITAMIN-E;

D O I：

10.1093/ajcn/62.6.1357S

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The oxidation of low-density lipoproteins (LDLs) is now commonly implicated as an important early event in atherogenesis. The resulting interest in LDL antioxidation has focused on ac-tocopherol, the biologically and chemically most active form of vitamin E and quantitatively the major lipid-soluble antioxidant in extracts prepared from human LDL. We review advances made in our understanding of the molecular action of cr-tocopherol in radical-mediated oxidation of isolated human LDL and how the vitamin's antioxidant activity is enhanced or even dependent on the presence of suitable reducing species, which are referred to as coantioxidants.

引用

页码：1357 / 1364

页数：8

共 66 条

[1] AUTOXIDATION IN MICELLES - SYNERGISM OF VITAMIN-C WITH LIPID-SOLUBLE VITAMIN-E AND WATER-SOLUBLE TROLOX [J].

BARCLAY, LRC ;

LOCKE, SJ ;

MACNEIL, JM .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1985, 63 (02) :366-374

[2] MINIMALLY MODIFIED LOW-DENSITY-LIPOPROTEIN STIMULATES MONOCYTE ENDOTHELIAL INTERACTIONS [J].

BERLINER, JA ;

TERRITO, MC ;

SEVANIAN, A ;

RAMIN, S ;

KIM, JA ;

BAMSHAD, B ;

ESTERSON, M ;

FOGELMAN, AM .

JOURNAL OF CLINICAL INVESTIGATION, 1990, 85 (04) :1260-1266

[3] REACTIONS OF THE ALPHA-TOCOPHEROXYL RADICAL IN MICELLAR SOLUTIONS STUDIED BY NANOSECOND LASER FLASH-PHOTOLYSIS [J].

BISBY, RH ;

PARKER, AW .

FEBS LETTERS, 1991, 290 (1-2) :205-208

[4] THE ANTIOXIDANT BUTYLATED HYDROXYTOLUENE PROTECTS AGAINST ATHEROSCLEROSIS [J].

BJORKHEM, I ;

HENRIKSSONFREYSCHUSS, A ;

BREUER, O ;

DICZFALUSY, U ;

BERGLUND, L ;

HENRIKSSON, P .

ARTERIOSCLEROSIS AND THROMBOSIS, 1991, 11 (01) :15-22

[5] TOCOPHEROL-MEDIATED PEROXIDATION - THE PROOXIDANT EFFECT OF VITAMIN-E ON THE RADICAL-INITIATED OXIDATION OF HUMAN LOW-DENSITY-LIPOPROTEIN [J].

BOWRY, VW ;

STOCKER, R .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (14) :6029-6044

[6] PREVENTION OF TOCOPHEROL-MEDIATED PEROXIDATION IN UBIQUINOL-10-FREE HUMAN LOW-DENSITY-LIPOPROTEIN [J].

BOWRY, VW ;

MOHR, D ;

CLEARY, J ;

STOCKER, R .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (11) :5756-5763

[7] VITAMIN-E IN HUMAN LOW-DENSITY-LIPOPROTEIN - WHEN AND HOW THIS ANTIOXIDANT BECOMES A PROOXIDANT [J].

BOWRY, VW ;

INGOLD, KU ;

STOCKER, R .

BIOCHEMICAL JOURNAL, 1992, 288 :341-344

[8] HIGH-DENSITY-LIPOPROTEIN IS THE MAJOR CARRIER OF LIPID HYDROPEROXIDES IN HUMAN BLOOD-PLASMA FROM FASTING DONORS [J].

BOWRY, VW ;

STANLEY, KK ;

STOCKER, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (21) :10316-10320

[9]

BURTON GW, 1986, ACCOUNTS CHEM RES, V19, P194, DOI 10.1021/ar00127a001

[10] ANTIATHEROGENIC EFFECT OF PROBUCOL UNRELATED TO ITS HYPOCHOLESTEROLEMIC EFFECT - EVIDENCE THAT ANTIOXIDANTS INVIVO CAN SELECTIVELY INHIBIT LOW-DENSITY-LIPOPROTEIN DEGRADATION IN MACROPHAGE-RICH FATTY STREAKS AND SLOW THE PROGRESSION OF ATHEROSCLEROSIS IN THE WATANABE HERITABLE HYPERLIPIDEMIC RABBIT [J].

CAREW, TE ;

SCHWENKE, DC ;

STEINBERG, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (21) :7725-7729

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