AUTONOMIC NERVOUS CONTROL OF BLOOD-PRESSURE AND HEART-RATE DURING HYPOXIA IN THE COD, GADUS-MORHUA

The autonomic nervous and possible adrenergic humoral control of blood pressure and heart rate during hypoxia was investigated in Atlantic cod. The oxygen tension in the water was reduced to 4.0-5.3 kPa (i.e.. PwO2=30-40 mmHg), and the fish responded with an immediate increase in ventral and dorsal aortic blood pressure (PvaPda), as well as a slowly developing bradycardia. The plasma concentrations of circulating catecholamines increased during hypoxia with a peak in the plasma level of noradrenaline occurring before the peak for adrenaline. Bretylium was used as a chemical tool to differentiate between neuronal and humoral adrenergic control of blood pressure and heart rate (fH) during hypoxia. The increase in Pva and Pda in response to hypoxia was strongly reduced in bretylium-treated cod, which suggests that adrenergic nerves are responsible for hypoxic hypertension. In addition, a small contribution by circulating catecholamines to the adrenergic tonus affecting Pva during hypoxia was suggested by the decrease in Pva induced by injection of the α-adrenoceptor antagonist phentolamine. The cholinergic and the adrenergic tonus affecting heart rate were estimated by injections of atropine and the β-adrenoceptor antagonist sotalol. The experiments demonstrate an increased cholicholinergic as well as adrenergic tonus on the heart during hypoxia. © 1990 Springer-Verlag.