DETECTION OF EPSTEIN-BARR VIRAL GENOMES IN LYMPH-NODES OF HODGKINS-DISEASE PATIENTS

被引：23

作者：

BIGNON, YJ

BERNARD, D

CURE, H

FONCK, Y

PAUCHARD, J

TRAVADE, P

LEGROS, M

DASTUGUE, B

PLAGNE, R

机构：

[1] INSERM,BIOCHIM MED LAB,CJF,F-88060 CLERMONT FERRAND,FRANCE

[2] HOP HOTEL DIEU,F-63003 CLERMONT FERRAND,FRANCE

[3] CTR HOSP MONTLUCON,MONTLUCON,FRANCE

来源：

MOLECULAR CARCINOGENESIS | 1990年 / 3卷 / 01期

关键词：

Epstein‐Barr virus; Key words; Polymerase chain reaction; Reed‐Sternberg cells;

D O I：

10.1002/mc.2940030105

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Previous studies using Southern blot analysis or in situ hybridization have shown that approximately 20% of patients with Hodgkin's disease have Epstein‐Barr virus (EBV) in involved tissues. We used the more sensitive polymerase chain reaction (PCR) technique to determine if a higher percentage of EBV could be detected. Of the 16 Hodgkin's disease patients studied, the PCR technique detected EBV in eight (50%). No prognostic significance was associated with the presence of EBV in the eight EBV‐positive patients, and the presence of EBV was not associated with B cell monoclonality. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

引用

页码：9 / 11

页数：3

共 4 条

[1]

DUGGAN DB, 1988, BLOOD, V71, P1027

[2] PRIMER-DIRECTED ENZYMATIC AMPLIFICATION OF DNA WITH A THERMOSTABLE DNA-POLYMERASE [J].