AGE-RELATED-CHANGES IN GLUTAMINE-SYNTHETASE ACTIVITY OF RAT-BRAIN, LIVER AND HEART

被引：14

作者：

DANH, HC ^{[1
]}

BENEDETTI, MS ^{[1
]}

DOSTERT, P ^{[1
]}

机构：

[1] CTR RECH DELALANDE, F-92500 RUEIL MALMAISON, FRANCE

来源：

GERONTOLOGY | 1985年 / 31卷 / 02期

关键词：

D O I：

10.1159/000212686

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Glutamine synthetase (GS) activity was measured in whole brain, different brain areas, liver and heart of 23- to 26-mo. old rats, and then it was compared to matched animals of 3 mo. A significant increase of GS activity was found in whole brain (25%) of old rats, as well as in all brain areas studied, but particularly in midbrain (36%), hypothalamus (32%), brainstem (32%), striatum (27%) and cerebellum (22%). A significant decrease of GS activity (21%) was found in liver, and no significant difference was found in heart of old rats when compared to matched animals of 3 mo. The present results suggest that an increase of GS activity in brain of old rats may be an adaptive phenomenon, and the regulatory mechanisms for GS with increasing age are different, depending on the tissues.

引用

页码：95 / 100

页数：6

共 52 条

[1]

AJIMONEMARSAN C, 1949, ELECTROEN CLIN NEURO, V1, P291

[2] DIFFERENTIAL CHANGES IN MONOAMINE OXIDASE-A AND B ACTIVITY IN THE AGING RAT-BRAIN [J].