EXTRATHYMIC ORIGIN OF INTESTINAL INTRAEPITHELIAL LYMPHOCYTES BEARING T-CELL ANTIGEN RECEPTOR-GAMMA-DELTA

被引：295

作者：

BANDEIRA, A

ITOHARA, S

BONNEVILLE, M

BURLENDEFRANOUX, O

MOTASANTOS, T

COUTINHO, A

TONEGAWA, S

机构：

[1] MIT, HOWARD HUGHES MED INST, CANC RES CTR, CAMBRIDGE, MA 02139 USA

[2] MIT, HOWARD HUGHES MED INST, DEPT BIOL, CAMBRIDGE, MA 02139 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 01期

关键词：

THYMECTOMY; THYMIC INDEPENDENCE; T-CELL ONTOGENY;

D O I：

10.1073/pnas.88.1.43

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The kinetics of postanatal intestinal colonization by T cells carrying gamma-delta and alpha-beta T-cell antigen receptors were studied in nude and normal mice by flow cytometry and immunohistology. Furthermore, gamma-delta and alpha-beta T-cell development was analyzed in lethally irradiated mice that were reconstituted by fetal liver precursors with or without a thymus. Our results establish that a major subpopulation of gamma-delta intestinal intraepithelial lymphocytes is produced from uncommitted precursors at extrathymic sites. This work further shows that a small pool of T cells carrying alpha-beta T-cell receptors can also differentiate extrathymically from CD3- fetal liver precursors but with rates of production and peripheral expansion much reduced as compared with those observed in thymus-bearing animals.

引用

页码：43 / 47

页数：5

共 44 条

[1] LIMITED DIVERSITY OF GAMMA-DELTA-ANTIGEN RECEPTOR GENES OF THY-1+ DENDRITIC EPIDERMAL-CELLS [J].