DUAL ROLE OF S-NITROSOCAPTOPRIL AS AN INHIBITOR OF ANGIOTENSIN-CONVERTING ENZYME AND A NITROSO GROUP CARRIER

被引：11

作者：

PARK, JW

机构：

[1] Department of Biochemistry, College of Natural Sciences, Kyungpook National University, Taegu

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 189卷 / 01期

关键词：

D O I：

10.1016/0006-291X(92)91545-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The S-nitroso derivatives of captopril can act as an inhibitor of an angiotensin-converting enzyme in the presence of thiol such as glutathione. S-Nitrosocaptopril also rapidly transfers its nitroso moiety to a heme protein, which is presumably the responsible mechanism for the activation of guanylate cyclase. These results suggest that S-nitrosocaptopril may serve as an effective hypotensive agent. © 1992.

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页码：206 / 210

页数：5

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