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IDENTIFICATION OF HUMAN TFIID COMPONENTS AND DIRECT INTERACTION BETWEEN A 250-KDA POLYPEPTIDE AND THE TATA BOX-BINDING PROTEIN (TFIID-TAU)

被引：65
作者：
TAKADA, R
NAKATANI, Y
HOFFMANN, A
KOKUBO, T
HASEGAWA, S
ROEDER, RG
HORIKOSHI, M
机构：
[1] NINCDS,MOLEC BIOL LAB,BETHESDA,MD 20892
[2] UNIV TOKYO,INST APPL MICROBIOL,BUNKYO KU,TOKYO 113,JAPAN
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 24期
关键词：
RNA POLYMERASE-II; TRANSCRIPTIONAL ACTIVATION; TRANSCRIPTION INITIATION; SUBUNIT STRUCTURE;
D O I：
10.1073/pnas.89.24.11809
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Previous studies have indicated that human transcription initiation factor TFIID is a large complex that contains a TATA-binding polypeptide (TFIIDtau or TBP) and other components that qualitatively alter promoter interactions and are uniquely required for activator-dependent (versus basal) transcription. TFIIDtau-specific antibody columns have been employed to identify a number of human TFIID polypeptides that are tightly associated with TFIIDtau. These differ in size from polypeptides in known general initiation factors, including the initiator-binding factor (TFII-I) which shares some promoter binding characteristics with TFIID. The largest component (p250) identified in TFIID was shown to interact directly and tightly with TFIIDtau, suggesting that it may play a major role in the assembly of the TFIID complex.
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收藏
页码：11809 / 11813
页数：5
相关论文
共 55 条
[1]   THE PSEUDORABIES IMMEDIATE EARLY PROTEIN STIMULATES INVITRO TRANSCRIPTION BY FACILITATING TFIID - PROMOTER INTERACTIONS [J].
ABMAYR, SM ;
WORKMAN, JL ;
ROEDER, RG .
GENES & DEVELOPMENT, 1988, 2 (05) :542-553
[2]   GENETIC ISOLATION OF ADA2 - A POTENTIAL TRANSCRIPTIONAL ADAPTER REQUIRED FOR FUNCTION OF CERTAIN ACIDIC ACTIVATION DOMAINS [J].
BERGER, SL ;
PINA, B ;
SILVERMAN, N ;
MARCUS, GA ;
AGAPITE, J ;
REGIER, JL ;
TRIEZENBERG, SJ ;
GUARENTE, L .
CELL, 1992, 70 (02) :251-265
[3]   FUNCTION OF A YEAST TATA ELEMENT-BINDING PROTEIN IN A MAMMALIAN TRANSCRIPTION SYSTEM [J].
BURATOWSKI, S ;
HAHN, S ;
SHARP, PA ;
GUARENTE, L .
NATURE, 1988, 334 (6177) :37-42
[4]   5 INTERMEDIATE COMPLEXES IN TRANSCRIPTION INITIATION BY RNA POLYMERASE-II [J].
BURATOWSKI, S ;
HAHN, S ;
GUARENTE, L ;
SHARP, PA .
CELL, 1989, 56 (04) :549-561
[5]   CLONING OF THE GENE ENCODING THE YEAST PROTEIN BTF1Y, WHICH CAN SUBSTITUTE FOR THE HUMAN TATA BOX-BINDING FACTOR [J].
CAVALLINI, B ;
FAUS, I ;
MATTHES, H ;
CHIPOULET, JM ;
WINSOR, B ;
EGLY, JM ;
CHAMBON, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (24) :9803-9807
[6]   A YEAST ACTIVITY CAN SUBSTITUTE FOR THE HELA-CELL TATA BOX FACTOR [J].
CAVALLINI, B ;
HUET, J ;
PLASSAT, JL ;
SENTENAC, A ;
EGLY, JM ;
CHAMBON, P .
NATURE, 1988, 334 (6177) :77-80
[7]   THE TATA-BINDING PROTEIN AND ASSOCIATED FACTORS ARE INTEGRAL COMPONENTS OF THE RNA POLYMERASE-I TRANSCRIPTION FACTOR, SL1 [J].
COMAI, L ;
TANESE, N ;
TJIAN, R .
CELL, 1992, 68 (05) :965-976
[8]  
CONAWAY JW, 1991, J BIOL CHEM, V266, P7804
[9]   FUNCTIONAL DIFFERENCES BETWEEN YEAST AND HUMAN TFIID ARE LOCALIZED TO THE HIGHLY CONSERVED REGION [J].
CORMACK, BP ;
STRUBIN, M ;
PONTICELLI, AS ;
STRUHL, K .
CELL, 1991, 65 (02) :341-348
[10]   FACTORS INVOLVED IN SPECIFIC TRANSCRIPTION BY MAMMALIAN RNA POLYMERASE-II - PURIFICATION AND ANALYSIS OF TRANSCRIPTION FACTOR-IIA AND IDENTIFICATION OF TRANSCRIPTION FACTOR-IIJ [J].
CORTES, P ;
FLORES, O ;
REINBERG, D .
MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (01) :413-421
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