RETROVIRUS VARIATION AND REVERSE TRANSCRIPTION - ABNORMAL STRAND TRANSFERS RESULT IN RETROVIRUS GENETIC-VARIATION

被引：266

作者：

TEMIN, HM

机构：

[1] McArdle Laboratory, University of Wisconsin, Madison, WI 53706

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 15期

关键词：

D O I：

10.1073/pnas.90.15.6900

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Human immunodeficiency virus variation is extensive and is based on numerous mistakes in reverse transcription. All retrovirus replication requires two strand transfers (growing point jumps) to synthesize the complete provirus. I propose that the numerous mistakes in reverse transcription are the result of this requirement for the two strand transfers needed to form the provirus.

引用

页码：6900 / 6903

页数：4

共 44 条

[1] RAPID DEVELOPMENT OF ISOLATE-SPECIFIC NEUTRALIZING ANTIBODIES AFTER PRIMARY HIV-1 INFECTION AND CONSEQUENT EMERGENCE OF VIRUS VARIANTS WHICH RESIST NEUTRALIZATION BY AUTOLOGOUS SERA [J].