CYCLIC HEXAPEPTIDE OXYTOCIN ANTAGONISTS - POTENCY-ENHANCING, SELECTIVITY-ENHANCING, AND SOLUBILITY-ENHANCING MODIFICATIONS

被引:26
作者
FREIDINGER, RM [1 ]
WILLIAMS, PD [1 ]
TUNG, RD [1 ]
BOCK, MG [1 ]
PETTIBONE, DJ [1 ]
CLINESCHMIDT, BV [1 ]
DIPARDO, RM [1 ]
ERB, JM [1 ]
GARSKY, VM [1 ]
GOULD, NP [1 ]
KAUFMAN, MJ [1 ]
LUNDELL, GF [1 ]
PERLOW, DS [1 ]
WHITTER, WL [1 ]
VEBER, DF [1 ]
机构
[1] MERCK SHARP & DOHME LTD,DEPT PHARMACEUT RES & DEV,W POINT,PA 19486
关键词
D O I
10.1021/jm00169a001
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Cyclic Hexapeptide Oxytocin Antagonists. Potency-, Selectivity-, and Solubility-Enhancing Modifications. © 1990, American Chemical Society. All rights reserved.
引用
收藏
页码:1843 / 1845
页数:3
相关论文
共 18 条
  • [1] ANTEUNIS MJO, 1988, INT J PEPT PROT RES, V31, P301
  • [2] BOCK MG, IN PRESS J MED CHEM
  • [3] PRACTICAL SYNTHESIS OF CYCLIC-PEPTIDES, WITH AN EXAMPLE OF DEPENDENCE OF CYCLIZATION YIELD UPON LINEAR SEQUENCE
    BRADY, SF
    VARGA, SL
    FREIDINGER, RM
    SCHWENK, DA
    MENDLOWSKI, M
    HOLLY, FW
    VEBER, DF
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1979, 44 (18) : 3101 - 3105
  • [4] CHAN WY, 1987, P SOC EXP BIOL MED, V185, P187
  • [5] CHENG Y, 1973, BIOCHEM PHARMACOL, V22, P3099
  • [6] DURETTE PL, UNPUB
  • [7] UBER DIE KATALYTISCHE HYDRIERUNG VON PYRAZINCARBONSAUREN
    FELDER, E
    MAFFEI, S
    PIETRA, S
    PITRE, D
    [J]. HELVETICA CHIMICA ACTA, 1960, 43 (03) : 888 - 896
  • [8] OXYTOCIN RECEPTORS AND HUMAN PARTURITION - A DUAL ROLE FOR OXYTOCIN IN THE INITIATION OF LABOR
    FUCHS, AR
    FUCHS, F
    HUSSLEIN, P
    SOLOFF, MS
    FERNSTROM, MJ
    [J]. SCIENCE, 1982, 215 (4538) : 1396 - 1398
  • [9] OXYTOCIN ANTAGONIST (DTVT) AND OXYTOCIN RECEPTORS IN MYOMETRIUM AND DECIDUA
    FUCHS, AR
    VANGSTED, A
    IVANISEVIC, M
    DEMAREST, K
    [J]. AMERICAN JOURNAL OF PERINATOLOGY, 1989, 6 (02) : 205 - 208
  • [10] AMINO-ACIDS AND PEPTIDES .21. SYNTHESIS OF A CONGENER OF THE CYCLOHEXADEPSIPEPTIDE ANTIBIOTIC, MONAMYCIN
    HASSALL, CH
    JOHNSON, WH
    THEOBALD, CJ
    [J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1979, (06): : 1451 - 1454