SPERM STIMULANTS CAN IMPROVE FERTILIZATION RATES IN MALE-FACTOR CASES UNDERGOING IVF TO THE SAME EXTENT AS MICROMANIPULATION BY PARTIAL ZONA DISSECTION (PZD) OR SUBZONAL SPERM INSEMINATION (SUZI) - A RANDOMIZED CONTROLLED-STUDY

被引：8

作者：

EDIRISINGHE, WR

JUNK, S

YOVICH, JM

BOOTSMA, B

YOVICH, JL

机构：

[1] PIVET Medical Centre, Leederville, Perth, 6007, Western Australia

来源：

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS | 1995年 / 12卷 / 05期

关键词：

PENTOXIFYLLINE; 2-DEOXYADENOSINE; IN VITRO FERTILIZATION; PARTIAL ZONA DISSECTION; SUBZONAL SPERM INSEMINATION;

D O I：

10.1007/BF02213710

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Purpose Our purpose was to evaluate the efficacy of direct insemination (IVF), micromanipulation by partial zona dissection (PZD), and subzonal sperm insemination (SUZI) using sperm-treated with pentoxifylline (PF) +/- 2-deoxyadenosine (2DA). Results: The overall fertilization rate achieved was similar for all three fertilization techniques (33.1, 30.2, and 26.9% for IVF, SUZI, and PZD, respectively). Patients who had reduced fertilization in previous IVF attempts showed improved fertilization with sperm stimulants, either PF alone or PF in combination with 2DA in standard IVF. In certain cases, SUZI or PZD gave significantly improved fertilization rates in comparison to IVF. Conclusion: Selective use of sperm stimulants in IVF can achieve fertilization for the majority of male-factor cases. However, PZD and SUZI techniques are useful, especially when sperm stimulants fail to achieve fertilization or achieve poor fertilization in direct insemination.

引用

页码：312 / 318

页数：7

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