RAPID SEPARATION OF DINUCLEOTIDES WITH ION-PAIR HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：4

作者：

BRUGGEMANN, B ^{[1
]}

SCHLUTER, H ^{[1
]}

VERSPOHL, EJ ^{[1
]}

ZIDEK, W ^{[1
]}

机构：

[1] INST PHARM CHEM,D-48149 MUNSTER,GERMANY

来源：

FRESENIUS JOURNAL OF ANALYTICAL CHEMISTRY | 1994年 / 350卷 / 12期

关键词：

D O I：

10.1007/BF00323672

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Since 5'5'-dinucleotides have been found in human organism, an increasing interest in separation methods of these compounds can be recognized. Their separation with conventional reversed-phase columns in the gradient elution mode affords more than 60 min. It has been demonstrated that an ion-pair reversed-phase HPLC based on perfusion chromatography achieves separation of dinucleotides within 10 min with high reproducibility, resolution and capacity.

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页码：719 / 721

页数：3

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