HLA AND PROGNOSIS IN MULTIPLE-SCLEROSIS

被引：59

作者：

RUNMARKER, B ^{[1
]}

MARTINSSON, T ^{[1
]}

WAHLSTROM, J ^{[1
]}

ANDERSEN, O ^{[1
]}

机构：

[1] OSTRA HOSP, DEPT CLIN GENET, S-41685 GOTHENBURG, SWEDEN

来源：

JOURNAL OF NEUROLOGY | 1994年 / 241卷 / 06期

关键词：

MULTIPLE SCLEROSIS; HLA ANTIGENS; PROGNOSIS; LIFE-TABLE ANALYSIS;

D O I：

10.1007/BF02033356

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The patients of a multiple sclerosis (MS) incidence cohort with 25 years of longitudinal follow-up were typed for HLA-DR and DQ. This type of cohort provides reliable data for gene frequencies and prognostic studies. The influence of sampling bias, mainly due to mortality during the long follow-up, was accounted for. A positive association between MS and DR15,DQ6 was confirmed, but this haplotype did not influence prognosis. There was no difference in haplotype frequency between relapsing-remitting and primary chronic progressive MS. DR17,DQ2 was significantly over-represented in the quartile with the most malignant course. The haplotype DRI,DQ5, which was found rather less frequently in MS patients, also tended to be associated with a poorer prognosis.

引用

页码：385 / 390

页数：6

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