8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN, A 5-HT1A RECEPTOR AGONIST, IMPAIRS PERFORMANCE IN A PASSIVE-AVOIDANCE TASK

被引:79
作者
CARLI, M [1 ]
TRANCHINA, S [1 ]
SAMANIN, R [1 ]
机构
[1] MARIO NEGRI INST PHARMACOL RES,VIA ERITREA 62,I-20157 MILAN,ITALY
关键词
8-OH-DPAT (8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN); 5-HT1A RECEPTORS; PASSIVE AVOIDANCE; MEMORY;
D O I
10.1016/0014-2999(92)90533-A
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The effects of various subcutaneous doses (30, 100 and 30-mu-s/kg) of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a serotonin (5-HT)1A receptor agonist, were studied on the performance of rats in a one-trial passive avoidance task. When administered 30 min before the training trial and the retention test, 8-OH-DPAT significantly reduced retention latencies at all doses. Similar results were obtained when 8-OH-DPAT was administered before either the training trial or the retention test. When administered 5 min after the training trial, 100 and 300-mu-g/kg 8-OH-DPAT significantly reduced the retention latencies whereas 30-mu-g/kg caused a non-significant tendency to a reduction. A dose of 300-mu-g/kg 8-OH-DPAT significantly raised the thresholds for various responses (flinch, jump and vocalization) elicited by electric shock applied to the grid floor while 30 and 100-mu-g/kg had no effect. When administered 30 min before the retention test to rats that could choose between a punished and unpunished compartment, 8-OH-DPAT at 100 and 300-mu-g/kg facilitated re-entry to either compartment but, like control animals, most 8-OH-DPAT-treated animals preferred the unpunished compartment. Although the effects of 8-OH-DPAT on pain perception, general activity or emotional behavior may interfere with the performance of rats in the passive avoidance task, the results suggest that at 100 and 300-mu/g/kg 8-OH-DPAT interferes with mechanisms related to the acquisition and consolidation of memory.
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页码:227 / 234
页数:8
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