SLOW BORDER CELLS, A LOCUS REQUIRED FOR A DEVELOPMENTALLY REGULATED CELL-MIGRATION DURING OOGENESIS, ENCODES DROSOPHILA C/EBP

被引：282

作者：

MONTELL, DJ ^{[1
]}

RORTH, P ^{[1
]}

SPRADLING, AC ^{[1
]}

机构：

[1] CARNEGIE INST WASHINGTON, HOWARD HUGHES MED INST, DEPT EMBRYOL, BALTIMORE, MD 21210 USA

来源：

CELL | 1992年 / 71卷 / 01期

关键词：

D O I：

10.1016/0092-8674(92)90265-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

During Drosophila oogenesis six to ten follicle cells, the border cells, undergo a dramatic and stereotypic migration through the developing egg chamber. We identified four independent P element insertion mutations that specifically blocked border cell migration. They defined a single, novel locus that was named slow border cells (slbo), because hypomorphic alleles caused delayed onset of the migration. Laser ablation of the border cells, or failure of their migration, caused improper morphogenesis of the micropyle, the eggshell structure through which the sperm enters at fertilization. The slbo locus was found to encode a product homologous to the CCAAT/enhancer-binding protein (C/EBP), a basic region-leucine zipper transcription factor. Drosophila C/EBP may be required for the expression of gene products mediating border cell migration.

引用

页码：51 / 62

页数：12

共 31 条

[1] P-ELEMENT-MEDIATED ENHANCER DETECTION - A VERSATILE METHOD TO STUDY DEVELOPMENT IN DROSOPHILA [J].

BELLEN, HJ ;

OKANE, CJ ;

WILSON, C ;

GROSSNIKLAUS, U ;

PEARSON, RK ;

GEHRING, WJ .

GENES & DEVELOPMENT, 1989, 3 (09) :1288-1300

[2]

BERG CA, 1991, GENETICS, V127, P515

[3] REGULATED EXPRESSION OF 3 C/EBP ISOFORMS DURING ADIPOSE CONVERSION OF 3T3-L1 CELLS [J].

CAO, ZD ;

UMEK, RM ;

MCKNIGHT, SL .

GENES & DEVELOPMENT, 1991, 5 (09) :1538-1552

[4] DIFFERENTIATION-INDUCED GENE-EXPRESSION IN 3T3-L1 PREADIPOCYTES - CCAAT ENHANCER BINDING-PROTEIN INTERACTS WITH AND ACTIVATES THE PROMOTERS OF 2 ADIPOCYTE-SPECIFIC GENES [J].

CHRISTY, RJ ;

YANG, VW ;

NTAMBI, JM ;

GEIMAN, DE ;

LANDSCHULZ, WH ;

FRIEDMAN, AD ;

NAKABEPPU, Y ;

KELLY, TJ ;

LANE, MD .

GENES & DEVELOPMENT, 1989, 3 (09) :1323-1335

[5] APTEROUS, A GENE REQUIRED FOR IMAGINAL DISK DEVELOPMENT IN DROSOPHILA ENCODES A MEMBER OF THE LIM FAMILY OF DEVELOPMENTAL REGULATORY PROTEINS [J].

COHEN, B ;

MCGUFFIN, ME ;

PFEIFLE, C ;

SEGAL, D ;

COHEN, SM .

GENES & DEVELOPMENT, 1992, 6 (05) :715-729

[6] INSERTIONAL MUTAGENESIS OF THE DROSOPHILA GENOME WITH SINGLE P-ELEMENTS [J].

COOLEY, L ;

KELLEY, R ;

SPRADLING, A .

SCIENCE, 1988, 239 (4844) :1121-1128

[7] A CONSERVED REGULATORY UNIT IMPLICATED IN TISSUE-SPECIFIC GENE-EXPRESSION IN DROSOPHILA AND MAN [J].

FALB, D ;

MANIATIS, T .

GENES & DEVELOPMENT, 1992, 6 (03) :454-465

[8] IDENTIFICATION OF 2 POLYPEPTIDE SEGMENTS OF CCAAT ENHANCER-BINDING PROTEIN REQUIRED FOR TRANSCRIPTIONAL ACTIVATION OF THE SERUM-ALBUMIN GENE [J].

FRIEDMAN, AD ;

MCKNIGHT, SL .

GENES & DEVELOPMENT, 1990, 4 (08) :1416-1426

[9] PARALLEL ASSOCIATION OF FOS AND JUN LEUCINE ZIPPERS JUXTAPOSES DNA-BINDING DOMAINS [J].

GENTZ, R ;

RAUSCHER, FJ ;

ABATE, C ;

CURRAN, T .

SCIENCE, 1989, 243 (4899) :1695-1699

[10]

GUTZEIT HO, 1982, J EMBRYOL EXP MORPH, V67, P101

← 1 2 3 4 →