B-I-B-II TRANSITIONS IN B-DNA

被引:140
作者
HARTMANN, B [1 ]
PIAZZOLA, D [1 ]
LAVERY, R [1 ]
机构
[1] INST BIOL PHYS CHIM,BIOCHIM THEOR LAB,CNRS,URA77,13 RUE PIERRE & MARIE CURIE,F-75005 PARIS,FRANCE
关键词
D O I
10.1093/nar/21.3.561
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Molecular modelling is used to study the conformational and energetic aspects of B(I)-B(II) transitions within the backbone of a B-DNA dodecamer d(CATGACGTCATG) whose fine structure has previously been determined by molecular modelling combined with NMR spectroscopy. It is shown that while the dodecamer under investigation does not contain any B(II) junctions, the central CpG step can most easily undergo the transition. More generally, it is also found that the base sequence and hence the backbone geometry of a DNA segment, strongly influences both the conformational impact of the transition, the associated energy barrier and the stability of the resulting B(II) state.
引用
收藏
页码:561 / 568
页数:8
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