TODRALAZINE INFLUENCE UPON THE MUTAGENICITY OF SOME DIRECT-ACTING AND INDIRECT-ACTING MUTAGENS

被引：8

作者：

GASIOROWSKI, K

SZYBA, K

URBAN, J

机构：

[1] Medical Academy, Department of Basic Medical Sciences, 51-601 Wroclaw

来源：

MUTATION RESEARCH | 1994年 / 324卷 / 03期

关键词：

AMES TEST; DIRECT MUTAGENS; INDIRECT MUTAGENS; TODRALAZINE ANTIMUTAGENICITY;

D O I：

10.1016/0165-7992(94)90057-4

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Todralazine decreased the mutagenic activity of tested direct- and indirect-acting mutagens. Despite the marked differences between efficient todralazine doses (ED(50)) it was observed that, in the case of tested indirect mutagens as well as in some of the direct mutagens, the decrease of mutagenicity by todralazine was very strong, exceeding 80% in some cases.

引用

页码：133 / 137

页数：5

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