TUMOR-SUPPRESSOR GENE-PRODUCTS IN CELL CONTACTS - THE CADHERIN-APC-ARMADILLO CONNECTION

被引：110

作者：

HULSKEN, J

BEHRENS, J

BIRCHMEIER, W

机构：

[1] Max-Delbruck-Center for Molecular Medicine, Berlin

来源：

CURRENT OPINION IN CELL BIOLOGY | 1994年 / 6卷 / 05期

关键词：

D O I：

10.1016/0955-0674(94)90098-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Various structural components of intercellular junctions have recently been found to represent (or be related to) products of tumor-suppressor genes. The tumor-suppressor gene product adenomatous polyposis coil (APC) binds to beta(2)-catenin (homologous to the product of Drosophila armadillo), which is cytoplasmically associated with the cell adhesion molecule E-cadherin.

引用

页码：711 / 716

页数：6

共 48 条

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