DECONTAMINATION STUDIES WITH THE AGENTS OF BOVINE SPONGIFORM ENCEPHALOPATHY AND SCRAPIE

被引：150

作者：

TAYLOR, DM ^{[1
]}

FRASER, H ^{[1
]}

MCCONNELL, I ^{[1
]}

BROWN, DA ^{[1
]}

BROWN, KL ^{[1
]}

LAMZA, KA ^{[1
]}

SMITH, GRA ^{[1
]}

机构：

[1] INST ANIM HLTH,MRC,NEUROPATHOGENESIS UNIT,EDINBURGH EH9 3JF,MIDLOTHIAN,SCOTLAND

来源：

ARCHIVES OF VIROLOGY | 1994年 / 139卷 / 3-4期

关键词：

D O I：

10.1007/BF01310794

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Macerates of bovine brain infected with bovine spongiform encephalopathy (BSE) agent, and rodent brain infected with the 263K or ME7 strains of scrapie agent, were subjected to porous-load autoclaving at temperatures between 134 and 138 degrees C for less than or equal to 60 min. Bioassay in rodents showed that none of the regimes produced complete inactivation. Homogenates of BSE-infected bovine brain were exposed for less than or equal to 120 min to solutions of sodium hypochlorite or sodium dichloroisocyanurate containing less than or equal to 16,500 ppm available chlorine. There was no detectable survival of infectivity after the hypochlorite treatments but none of the dichloroisocyanurate solutions produced complete inactivation. Homogenates of BSE-infected bovine brain, and rodent brain infected with the 263K and ME7 strains of scrapie agent, were exposed for less than or equal to 120 min to 1M or 2M sodium hydroxide but no procedure produced complete inactivation of all agents tested.

引用

页码：313 / 326

页数：14

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