NUCLEAR FACTORS IN SEVENLESS SIGNALING

被引：52

作者：

DICKSON, B

机构：

[1] Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley

来源：

TRENDS IN GENETICS | 1995年 / 11卷 / 03期

关键词：

D O I：

10.1016/S0168-9525(00)89011-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Recent studies in both vertebrates and invertebrates support all 'hourglass' model for signal transduction from receptor tyrosine kilnases: Ras channels signals front diverse receptor tyrosine kinases into a common cytoplasmic kinase cascade, the targets of which are an even more diverse collection of nuclear proteins. What are these nuclear factors, and bow do they interact to direct specific cellular responses to a generic signal? The past year has brought considerable progress in our quest to answer these questions in one model genetic system, the Drosophila eye.

引用

页码：106 / 111

页数：6

共 50 条

[1] REPROGRAMMING CELL FATE IN THE DEVELOPING DROSOPHILA RETINA - TRANSFORMATION OF R7-CELLS BY ECTOPIC EXPRESSION OF ROUGH [J].

BASLER, K ;

YEN, D ;

TOMLINSON, A ;

HAFEN, E .

GENES & DEVELOPMENT, 1990, 4 (05) :728-739

[2]

BASLER K, 1989, DEVELOPMENT, V107, P723

[3] LIGAND-INDEPENDENT ACTIVATION OF THE SEVENLESS RECEPTOR TYROSINE KINASE CHANGES THE FATE OF CELLS IN THE DEVELOPING DROSOPHILA EYE [J].

BASLER, K ;

CHRISTEN, B ;

HAFEN, E .

CELL, 1991, 64 (06) :1069-1081

[4] COOPERATIVE INTERACTION BETWEEN ETS AND AP-1 TRANSCRIPTION FACTORS REGULATES INDUCTION OF GLUTATHIONE-S-TRANSFERASE YA GENE-EXPRESSION [J].

BERGELSON, S ;

DANIEL, V .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 200 (01) :290-297

[5] THE DROSOPHILA ROLLED LOCUS ENCODES A MAP KINASE REQUIRED IN THE SEVENLESS SIGNAL-TRANSDUCTION PATHWAY [J].

BIGGS, WH ;

ZAVITZ, KH ;

DICKSON, B ;

VANDERSTRATEN, A ;

BRUNNER, D ;

HAFEN, E ;

ZIPURSKY, SL .

EMBO JOURNAL, 1994, 13 (07) :1628-1635

[6] DROSOPHILA JUN MEDIATES RAS-DEPENDENT PHOTORECEPTOR DETERMINATION [J].

BOHMANN, D ;

ELLIS, MC ;

STASZEWSKI, LM ;

MLODZIK, M .

CELL, 1994, 78 (06) :973-986

[7] THE SON OF SEVENLESS GENE-PRODUCT - A PUTATIVE ACTIVATOR OF RAS [J].

BONFINI, L ;

KARLOVICH, CA ;

DASGUPTA, C ;

BANERJEE, U .

SCIENCE, 1992, 255 (5044) :603-606

[8] THE ETS DOMAIN PROTEIN POINTED-P2 IS A TARGET OF MAP KINASE IN THE SEVENLESS SIGNAL-TRANSDUCTION PATHWAY [J].

BRUNNER, D ;

DUCKER, K ;

OELLERS, N ;

HAFEN, E ;

SCHOLZ, H ;

KLAMBT, C .

NATURE, 1994, 370 (6488) :386-389

[9] A GAIN-OF-FUNCTION MUTATION IN DROSOPHILA MAP KINASE ACTIVATES MULTIPLE RECEPTOR TYROSINE KINASE SIGNALING PATHWAYS [J].

BRUNNER, D ;

OELLERS, N ;

SZABAD, J ;

BIGGS, WH ;

ZIPURSKY, SL ;

HAFEN, E .

CELL, 1994, 76 (05) :875-888

[10] 7 IN ABSENTIA, A GENE REQUIRED FOR SPECIFICATION OF R7 CELL FATE IN THE DROSOPHILA EYE [J].

CARTHEW, RW ;

RUBIN, GM .

CELL, 1990, 63 (03) :561-577

← 1 2 3 4 5 →