Clinical relevance of hepatitis C virus quasispecies

被引：11

作者：

Enomoto, N ^{[1
]}

Sato, C ^{[1
]}

机构：

[1] TOKYO MED & DENT UNIV,FAC MED,DIV HLTH SCI,BUNKYO KU,TOKYO 113,JAPAN

来源：

JOURNAL OF VIRAL HEPATITIS | 1995年 / 2卷 / 06期

关键词：

hepatitis C virus; interferon; quasispecies;

D O I：

10.1111/j.1365-2893.1995.tb00040.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

It has been shown that hepatitis C virus (HCV) populations in infected individuals are composed of quasispecies with diverse mutations. The analysis of these variants may reveal mechanisms of the persistence of HCV infection, carcinogenesis and resistance to antiviral therapy. Recently, genetic features of interferon-resistant HCV have been elucidated through the analysis of interferon-resistant quasispecies, making it possible to predict interferon efficacy by detecting interferon-resistant strains.

引用

页码：267 / 272

页数：6

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