EXTREME DISCORDANT SIB PAIRS FOR MAPPING QUANTITATIVE TRAIT LOCI IN HUMANS

被引：453

作者：

RISCH, N ^{[1
]}

ZHANG, HP ^{[1
]}

机构：

[1] YALE UNIV, SCH MED, DEPT GENET, DEPT EPIDEMIOL & PUBL HLTH, NEW HAVEN, CT 06520 USA

来源：

SCIENCE | 1995年 / 268卷 / 5217期

关键词：

D O I：

10.1126/science.7777857

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Analysis of differences between siblings (sib pair analysis) is a standard method of genetic linkage analysis for mapping quantitative trait loci, such as those contributing to hypertension and obesity, in humans. In traditional designs, pairs are selected at random or with one sib having an extreme trait value. The majority of such pairs provide little power to detect linkage; only pairs that are concordant for high values, low values, or extremely discordant pairs (for example, one in the top 10 percent and the other in the bottom 10 percent of the distribution) provide substantial power. Focus on discordant pairs can reduce the amount of genotyping necessary over conventional designs by 10- to 40-fold.

引用

页码：1584 / 1589

页数：6

共 17 条

[1] ROBUST METHODS FOR THE DETECTION OF GENETIC-LINKAGE FOR QUANTITATIVE DATA FROM PEDIGREES [J].

AMOS, CI ;

ELSTON, RC .

GENETIC EPIDEMIOLOGY, 1989, 6 (02) :349-360

[2] POWER AND ROBUSTNESS OF SIB-PAIR LINKAGE TESTS AND EXTENSION TO LARGER SIBSHIPS [J].

BLACKWELDER, WC ;

ELSTON, RC .

COMMUNICATIONS IN STATISTICS PART A-THEORY AND METHODS, 1982, 11 (05) :449-484

[3] QUANTITATIVE TRAIT LOCUS FOR READING-DISABILITY ON CHROMOSOME-6 [J].

CARDON, LR ;

SMITH, SD ;

FULKER, DW ;

KIMBERLING, WJ ;

PENNINGTON, BF ;

DEFRIES, JC .

SCIENCE, 1994, 266 (5183) :276-279

[4]

CARDON LR, 1994, AM J HUM GENET, V55, P825

[5]

CAREY G, 1991, AM J HUM GENET, V49, P786

[6] A GENOME-WIDE SEARCH FOR HUMAN TYPE-1 DIABETES SUSCEPTIBILITY GENES [J].

DAVIES, JL ;

KAWAGUCHI, Y ;

BENNETT, ST ;

COPEMAN, JB ;

CORDELL, HJ ;

PRITCHARD, LE ;

REED, PW ;

GOUGH, SCL ;

JENKINS, SC ;

PALMER, SM ;

BALFOUR, KM ;

ROWE, BR ;

FARRALL, M ;

BARNETT, AH ;

BAIN, SC ;

TODD, JA .

NATURE, 1994, 371 (6493) :130-136

[7]

DAVIES JL, 1994, NATURE, V371, P161

[8]

Falconer D. S., 1996, Introduction to quantitative genetics.

[9] MULTIPLE-REGRESSION ANALYSIS OF SIB-PAIR DATA ON READING TO DETECT QUANTITATIVE TRAIT LOCI [J].

FULKER, DW ;

CARDON, LR ;

DEFRIES, JC ;

KIMBERLING, WJ ;

PENNINGTON, BF ;

SMITH, SD .

READING AND WRITING, 1991, 3 (3-4) :299-313

[10]

FULKER DW, 1994, AM J HUM GENET, V54, P1092

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