QUANTITATIVE CONTROL ANALYSIS OF BRANCHED-CHAIN 2-OXO ACID DEHYDROGENASE COMPLEX ACTIVITY BY FEEDBACK INHIBITION

被引：11

作者：

BOYER, B

ODESSEY, R

机构：

[1] Louisiana State University, Medical Center, Department of Physiology, New Orleans, LA 70112

来源：

BIOCHEMICAL JOURNAL | 1990年 / 271卷 / 02期

关键词：

D O I：

10.1042/bj2710523

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The potential for branched-chain 2-oxo acid dehydrogenase complex (BCOADC) activity to be controlled by feedback inhibition was investigated by calculating the Elasticity Coefficients for several feedback inhibitors. We suggest that feedback inhibition is a quantitatively important regulatory mechanism by which branched-chain 2-oxo acid dehydrogenase activity is regulated. The potential for control of enzyme activity is greater for NADH than for the acyl-CoA products, and suggests that factors that alter the redox potential may physiologically regulate BCOADC activity through a feedback inhibitory mechanism in vivo. Local pH may also be an important regulatory control factor.

引用

页码：523 / 528

页数：6

共 31 条

[1] EFFECTS OF THYROID-HORMONE DEFICIENCY ON DISTRIBUTION OF HEPATIC METABOLITES AND CONTROL OF PATHWAYS OF CARBOHYDRATE-METABOLISM IN LIVER AND ADIPOSE-TISSUE OF RAT [J].