FOLLICULAR-FLUID RENIN CONCENTRATION AND IVF OUTCOME

被引：17

作者：

CORNWALLIS, CM ^{[1
]}

SKINNER, SL ^{[1
]}

NAYUDU, PL ^{[1
]}

LOPATA, A ^{[1
]}

THATCHER, RL ^{[1
]}

YEUNG, SP ^{[1
]}

WHITWORTH, JA ^{[1
]}

机构：

[1] UNIV MELBOURNE,DEPT PHYSIOL,PARKVILLE,VIC 3052,AUSTRALIA

来源：

HUMAN REPRODUCTION | 1990年 / 5卷 / 04期

基金：

英国医学研究理事会;

关键词：

Gonadotrophin; Growth factors; Oocyte maturation; Ovarian renin-angiotensin system; Ovum viability; Renin gene expression;

D O I：

10.1093/oxfordjournals.humrep.a137113

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Total renin protein concentration (TRC) was measured in stored follicular fluid (FF) samples from 42 women. Samples were selected according to their origin from follicles either without recovered ova ('empty', n = 38) or fertilized but with failed implantation ('failed', n = 36) or successful deliveries ('deliveries', n = 71). Ratios of number of embryos transfered to number of infants delivered were 2:1, 3:1 or 4:2 but 1:1 was not available. Non-parametric testing was applied to FF-TRC, volume and outcome. TRC was significantly higher in the delivery than the failed (P = 0.001) or empty (P = 0.002) categories. Assuming that the range of renin in failed follicles can identify the sub-population of unsuccessful follicles in the delivery category, then elevated FF-TRC was clearly associated with successful outcome. For individual women, the odds of infant delivery increased 17-fold as a function of average FF-TRC between 10 000 and 25 000 μIU/ml. For failed and delivery but not empty follicles, higher renin levels occurred in the smaller follicles, consistent with a burst of renin synthesis associated with the presence of an oocyte. The results suggest that FF-TRC relates to ovum viability with ovarian hyperstimulation and may have predictive use in IVF programmes. © 1990 Oxford University Press.

引用

页码：413 / 417

页数：5

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