RIBONUCLEASE MIMICS

被引：63

作者：

BRESLOW, R

ANSLYN, E

HUANG, DL

机构：

[1] Department of Chemistry, Columbia University New York

来源：

TETRAHEDRON | 1991年 / 47卷 / 14-15期

关键词：

D O I：

10.1016/S0040-4020(01)81774-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The cleavage of the ribonucleotide UpU by imidazole buffers shows kinetic behavior that indicates a sequential bifunctional mechanism, in which the imidazolium ion acts first. Similar results are obtained for the cleavage of ApA. This mechanism is related to the simultaneous bifunctional cleavage of RNA by the enzyme ribonuclease, and has guided us to the synthesis of an improved cyclodextrin-bis-imidazole enzyme mimic that also uses a simultaneous bifunctional mechanism.

引用

页码：2365 / 2376

页数：12

共 17 条

[1] ON THE MECHANISM OF CATALYSIS BY RIBONUCLEASE - CLEAVAGE AND ISOMERIZATION OF THE DINUCLEOTIDE UPU CATALYZED BY IMIDAZOLE BUFFERS
ANSLYN, E
BRESLOW, R
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (12) : 4473 - 4482
[2] PROTON INVENTORY OF A BIFUNCTIONAL RIBONUCLEASE MODEL
ANSLYN, E
BRESLOW, R
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (24) : 8931 - 8932
[3] GEOMETRIC EVIDENCE ON THE RIBONUCLEASE MODEL MECHANISM
ANSLYN, E
BRESLOW, R
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[4] Blackburn P, 1982, ENZYMES, VXV, P317
[5] ON THE MECHANISM OF ACTION OF RIBONUCLEASES - DINUCLEOTIDE CLEAVAGE CATALYZED BY IMIDAZOLE AND ZN-2+
BRESLOW, R
HUANG, DL
ANSLYN, E
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[6] PARTITIONING RATIOS AND A BIOCHEMICAL KINETIC DILEMMA - THE PH-DEPENDENCE OF CHYMOTRYPSIN CATALYSIS
BRESLOW, R
[J]. JOURNAL OF CHEMICAL EDUCATION, 1990, 67 (03) : 228 - 229
[7] REVERSING THE SELECTIVITY OF CYCLODEXTRIN BISIMIDAZOLE RIBONUCLEASE MIMICS BY CHANGING THE CATALYST GEOMETRY
BRESLOW, R
BOVY, P
HERSH, CL
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1980, 102 (06) : 2115 - 2117
[8] BRESLOW R, 1986, ADV ENZYMOL RAMB, V58, P1
[9] BETA-CYCLODEXTRINYLBISIMIDAZOLE, A MODEL FOR RIBONUCLEASE
BRESLOW, R
DOHERTY, JB
GUILLOT, G
LIPSEY, C
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[10] SEQUENTIAL GENERAL BASE ACID CATALYSIS IN THE HYDROLYSIS OF RNA BY IMIDAZOLE
BRESLOW, R
LABELLE, M
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (10) : 2655 - 2659

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