DIASTEREOMERIC BETA-LACTAM ANTIBIOTICS - ANALYTICAL METHODS, ISOMERIZATION AND STEREOSELECTIVE PHARMACOKINETICS

被引：13

作者：

ITOH, T ^{[1
]}

YAMADA, H ^{[1
]}

机构：

[1] KITASATO UNIV, SCH PHARMACEUT SCI, DEPT PHAMACOKINET & BIOPHARMACEUT, MINATO KU, TOKYO 108, JAPAN

来源：

JOURNAL OF CHROMATOGRAPHY A | 1995年 / 694卷 / 01期

关键词：

D O I：

10.1016/0021-9673(94)00932-Y

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Stereospecific HPLC methods for the determination of various diastereomeric beta-lactam antibiotics are reviewed. Stereoselectivity in the absorption, distribution and excretion of several diastereomeric beta-lactams is summarized. The isomerization of beta-lactam isomers and its influence on the pharmacokinetics and pharmacodynamics are discussed.

引用

页码：195 / 208

页数：14

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