EPIDERMAL GROWTH-FACTOR AND TRANSFORMING GROWTH-FACTOR-ALPHA MESSENGER-RNA IN RAT SMALL-INTESTINE - IN-SITU HYBRIDIZATION STUDY

被引：27

作者：

DVORAK, B

HOLUBEC, H

LEBOUTON, AV

WILSON, JM

KOLDOVSKY, O

机构：

[1] UNIV ARIZONA,COLL MED,STEELE MEM CHILDRENS RES CTR,TUCSON,AZ 85724

[2] UNIV ARIZONA,COLL MED,DEPT MED,TUCSON,AZ 85724

[3] UNIV ARIZONA,COLL MED,DEPT ANAT,TUCSON,AZ 85724

来源：

FEBS LETTERS | 1994年 / 352卷 / 03期

关键词：

EPIDERMAL GROWTH FACTOR; GASTROINTESTINAL TRACT; SUBMANDIBULAR GLAND; TRANSFORMING GROWTH FACTOR-ALPHA; IN SITU HYBRIDIZATION;

D O I：

10.1016/0014-5793(94)00942-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The expression of epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-alpha) mRNA in the small intestine of suckling and adult rats was examined by in situ hybridization. EGF mRNA was found mainly in the intestinal crypts in adult rats. Adult rats also exhibited a considerably stronger signal for EGF mRNA in comparison to suckling rats, where the signal was very low or absent. In contrast to EGF, very strong expression of TGF-alpha mRNA was observed in the small intestine of both adult and suckling rats. These data suggest the differences between the expression of EGF and TGF-alpha in the developing small intestine.

引用

页码：291 / 295

页数：5

共 51 条

[1] TRANSFORMING GROWTH-FACTOR-ALPHA IMMUNOREACTIVITY IN A VARIETY OF EPITHELIAL TISSUES [J].