SOLID LIPOSPHERES OF DOXORUBICIN AND IDARUBICIN

被引：105

作者：

CAVALLI, R ^{[1
]}

CAPUTO, O ^{[1
]}

GASCO, MR ^{[1
]}

机构：

[1] UNIV TURIN,DIPARTIMENTO SCI & TECNOL FARM,VIA P GIURIA 9,I-10125 TURIN,ITALY

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1993年 / 89卷 / 01期

关键词：

LIPOSPHERE; DOXORUBICIN; IDARUBICIN; MICROEMULSION;

D O I：

10.1016/0378-5173(93)90313-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Solid lipospheres, constituted mainly of stearic acid and egg lecithin, containing amounts of doxorubicin and idarubicin up to 7 and 8.4%, respectively, were prepared. The high incorporation of drug is due to an increase in their lipophilicity as a result of the formation of ion-pairs with monoalkyl phosphate esters.

引用

页码：R9 / R12

页数：4

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