VASCULAR-PERMEABILITY FACTOR ACCELERATES ENDOTHELIAL REGROWTH FOLLOWING BALLOON ANGIOPLASTY

被引：51

作者：

CALLOW, AD ^{[1
]}

CHOI, ET ^{[1
]}

TRACHTENBERG, JD ^{[1
]}

STEVENS, SL ^{[1
]}

CONNOLLY, DT ^{[1
]}

RODI, C ^{[1
]}

RYAN, US ^{[1
]}

机构：

[1] MONSANTO CO,ST LOUIS,MO 63167

来源：

GROWTH FACTORS | 1994年 / 10卷 / 03期

关键词：

VASCULAR PERMEABILITY FACTOR; RE-ENDOTHELIALIZATION; BALLOON ANGIOPLASTY;

D O I：

10.3109/08977199409000240

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Many failures of vascular reconstructions are due to thrombosis and restenosis and are often attributed to inadequate endothelial regeneration at the site of endothelial denudation. Vascular permeability factor (VPF) is a naturally occurring growth factor responsible for vessel permeability and microvascular angiogenesis. Here, we show that VPF stimulated rabbit endothelial cell proliferation in vitro at concentrations 100 ng/ml. However, VPF had no effect on smooth muscle cell proliferation at these concentrations up to 500 ng/ml. When VPF was administered for 4 weeks (120 mu g, twice weekly, i.v.) following balloon angioplasty-induced endothelial denudation of rabbit carotid artery, there was a significant increase in the in vivo regeneration of endothelium compared to control (57.5 +/- 6.7% vs. 38.3 +/- 1.9%, P < 0.01). Moreover, 8 weeks of VPF administration resulted in 88.1 +/- 3.1% re-endothelialization compared to control (44.7 +/- 3.8%). Hence, VPF appears to be a specific mitogen for endothelial regeneration.

引用

页码：223 / 228

页数：6

共 26 条

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