SOLID-PHASE SYNTHESIS AND IMMUNOREACTIVITY OF PENTA-O-(N-ACETYL ALPHA-D-GALACTOSAMINYL)-MUC1 EICOSAPEPTIDE, A GLYCOSYLATED COUNTER PART OF THE HIGHLY IMMUNOGENIC TANDEM REPEAT SEQUENCE OF CARCINOMA-ASSOCIATED MUCIN

被引：8

作者：

DUPRADEAU, FY

STROUD, MR

BOIVIN, D

LI, LS

HAKOMORI, S

SINGHAL, AK

TOYOKUNI, T

机构：

[1] BIOMEMBRANE INST,SEATTLE,WA 98119

[2] UNIV WASHINGTON,DEPT PATHOL,SEATTLE,WA 98119

[3] UNIV WASHINGTON,DEPT CHEM,SEATTLE,WA 98195

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 15期

关键词：

D O I：

10.1016/S0960-894X(01)80376-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Penta-O-glycosylated MUC1 peptide H-Val-Thr*-Ser*-Ala-Pro-Asp-Thr*-Arg-Pro-Ala-Pro-Gly-Ser*-Thr*-Ala-Pro-Pro-Ala-His-Gly-OH (*alpha-D-GalNAcp) (2) has been synthesized by a solid-phase method on Sasrin resin using Fmoc-glycoaminoacids 3 and 4 as building blocks. The monoclonal antibodies SM3 and HMPV, specific to the MUC1 peptide 1, also react strongly with 2.

引用

页码：1813 / 1818

页数：6

共 36 条

[1] EFFECTS OF GLYCOSYLATION ON PEPTIDE BACKBONE CONFORMATION [J].