CORRELATION-ANALYSIS IN LIQUID-CHROMATOGRAPHY OF METAL-CHELATES .1. ONE-DIMENSIONAL RETENTION STRUCTURE MODELS IN REVERSED-PHASE THIN-LAYER CHROMATOGRAPHY

The predictive abilities of some parameters describing the effect of the structure of metal chelates on their chromatographic properties in reversed-phase thin-layer chromatography are compared. The applicability of corresponding one-dimensional equations for an a priori estimation of retention parameters, for optimization of the chelating reagent and for studying the mechanism of the interphase distribution of metal chelates is demonstrated. The dependences of the capacity factors on molecular structure parameters (distribution constant, stability constant, molecular connectivity index) are shown to possess the highest correlation factors. The necessity for the development of a multi-parametric model for describing the dependence of the chromatographic properties of chelates on their structure and the chromatographic experimental conditions is substantiated. © 1990.