DEFINING THE SCHIZOPHRENIA SPECTRUM - ISSUES FOR GENETIC-LINKAGE STUDIES

被引:45
作者
LEVINSON, DF
MOWRY, BJ
机构
[1] WOLSTON PK HOSP,CLIN STUDIES UNIT,BRISBANE,QLD,AUSTRALIA
[2] UNIV QUEENSLAND,PSYCHIAT,ST LUCIA,QLD 4067,AUSTRALIA
关键词
D O I
10.1093/schbul/17.3.491
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Genetic linkage studies of schizophrenia depend on accurate psychiatric diagnosis of relatives within multiply affected families. Each investigator makes a series of explicit or implicit decisions to define which relatives will be assumed to share a schizophrenia-related genotype, that is, who is an "affected relative." In this article we delineate issues that we believe should be considered in such studies and review the relevant literature. Issues include criteria for selecting probands; whether broader criteria should be used to select affected relatives; approaches to including or excluding diagnoses for which family study data suggest a relationship to schizophrenia or to affective disorders or other psychiatric disorders; clarification of diagnostic hierarchy; and issues related to substance abuse and neurological disorders. Also discussed are whether relatives without spectrum diagnoses should be considered unaffected or undiagnosed in linkage analyses, how bilateral familial affectedness should be defined, and provision for independent review of study diagnoses. As an illustration, the clinical model for the authors' schizophrenia linkage study is described.
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页码:491 / 514
页数:24
相关论文
共 113 条
[1]  
ABRAMS R, 1983, AM J PSYCHIAT, V140, P171
[2]  
American Psychiatric Association, 1987, DIAGNOSTIC STAT MANU, V3rd
[3]  
American Psychiatric Association, 1980, DIAGN STAT MAN MENT, V3rd
[4]  
ANDREASENNC, 1985, COMPREHENSIVE ASSESS
[5]   NO EVIDENCE FOR LINKAGE BETWEEN CHROMOSOME-5 MARKERS AND SCHIZOPHRENIA [J].
ASCHAUER, HN ;
ASCHAUERTREIBER, G ;
ISENBERG, KE ;
TODD, RD ;
KNESEVICH, MA ;
GARVER, DL ;
REICH, T ;
CLONINGER, CR .
HUMAN HEREDITY, 1990, 40 (02) :109-115
[6]   SCHIZOAFFECTIVE ILLNESS, SCHIZOPHRENIA AND AFFECTIVE-DISORDERS - MORBIDITY RISK AND GENETIC TRANSMISSION [J].
BARON, M ;
GRUEN, R ;
ASNIS, L ;
KANE, J .
ACTA PSYCHIATRICA SCANDINAVICA, 1982, 65 (04) :253-262
[7]   THE SCHEDULE FOR SCHIZOTYPAL PERSONALITIES (SSP) - A DIAGNOSTIC INTERVIEW FOR SCHIZOTYPAL FEATURES [J].
BARON, M ;
ASNIS, L ;
GRUEN, R .
PSYCHIATRY RESEARCH, 1981, 4 (02) :213-228
[8]  
BARON M, 1985, AM J PSYCHIAT, V142, P697
[9]   GENETIC-LINKAGE IN MENTAL-ILLNESS [J].
BARON, M .
NATURE, 1990, 346 (6285) :618-618
[10]  
BARON M, 1985, AM J PSYCHIAT, V142, P447