THE NASAL DELIVERY OF PEPTIDES AND PROTEINS

被引：32

作者：

ILLUM, L ^{[1
]}

机构：

[1] DANBIOSYST UK LTD,NOTTINGHAM NG7 2RQ,ENGLAND

来源：

TRENDS IN BIOTECHNOLOGY | 1991年 / 9卷 / 08期

关键词：

D O I：

10.1016/0167-7799(91)90091-U

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Many drugs of the future will be therapeutically active peptides and proteins developed through recombinant-DNA technology. A major factor limiting their exploitation is the current lack of appropriate non-parenteral delivery systems. Nasal systems incorporating absorption enhancers may provide a convenient, efficient means of administering protein and peptide therapeutics.

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页码：284 / 289

页数：6

相关论文

共 47 条

[1] SITE DEPENDENCE OF ABSORPTION-PROMOTING ACTIONS OF LAURETH-9, NA SALICYLATE, NA2EDTA, AND APROTININ ON RECTAL, NASAL, AND BUCCAL INSULIN DELIVERY [J].

AUNGST, BJ ;

ROGERS, NJ .

PHARMACEUTICAL RESEARCH, 1988, 5 (05) :305-308

[2]

AZRIA M, Patent No. 2127689

[3] THE EFFECT OF SODIUM TAURO-24,25-DIHYDROFUSIDATE ON THE NASAL ABSORPTION OF HUMAN GROWTH-HORMONE IN 3 ANIMAL-MODELS [J].

BALDWIN, PA ;

KLINGBEIL, CK ;

GRIMM, CJ ;

LONGENECKER, JP .

PHARMACEUTICAL RESEARCH, 1990, 7 (05) :547-552

[4] PRODRUGS OF PEPTIDES .6. BIOREVERSIBLE DERIVATIVES OF THYROTROPIN-RELEASING-HORMONE (TRH) WITH INCREASED LIPOPHILICITY AND RESISTANCE TO CLEAVAGE BY THE TRH-SPECIFIC SERUM ENZYME [J].

BUNDGAARD, H ;

MOSS, J .

PHARMACEUTICAL RESEARCH, 1990, 7 (09) :885-892

[5]

CHIEN YW, 1989, NASAL SYSTEMIC DRUG, V39

[6] ABSORPTION OF RECOMBINANT METHIONYL-HUMAN GROWTH-HORMONE (MET-HGH) FROM RAT NASAL-MUCOSA [J].

DAUGHERTY, AL ;

LIGGITT, HD ;

MCCABE, JG ;

MOORE, JA ;

PATTON, JS .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1988, 45 (03) :197-206

[7] ABSORPTION OF POLYETHYLENE GLYCOL-600 THROUGH POLYETHYLENE GLYCOL-2000 - THE MOLECULAR-WEIGHT DEPENDENCE OF GASTROINTESTINAL AND NASAL ABSORPTION [J].

DONOVAN, MD ;

FLYNN, GL ;

AMIDON, GL .

PHARMACEUTICAL RESEARCH, 1990, 7 (08) :863-868

[8] THE EFFECTS OF PERMEATION ENHANCERS ON THE SURFACE-MORPHOLOGY OF THE RAT NASAL-MUCOSA - A SCANNING ELECTRON-MICROSCOPY STUDY [J].

ENNIS, RD ;

BORDEN, L ;

LEE, WA .

PHARMACEUTICAL RESEARCH, 1990, 7 (05) :468-475

[9] MECHANISM OF NASAL ABSORPTION OF DRUGS .3. NASAL ABSORPTION OF LEUCINE ENKEPHALIN [J].

FARAJ, JA ;

HUSSAIN, AA ;

ARAMAKI, Y ;

ISEKI, K ;

KAGOSHIMA, M ;

DITTERT, LW .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1990, 79 (08) :698-702

[10] NASAL ADMINISTRATION OF INSULIN USING BIOADHESIVE MICROSPHERES AS A DELIVERY SYSTEM [J].

FARRAJ, NF ;

JOHANSEN, BR ;

DAVIS, SS ;

ILLUM, L .

JOURNAL OF CONTROLLED RELEASE, 1990, 13 (2-3) :253-261

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