TECHNICAL CHALLENGES ASSOCIATED WITH THE RADIOLABELING OF MONOCLONAL-ANTIBODIES UTILIZING SHORT-LIVED, POSITRON EMITTING RADIONUCLIDES

被引：12

作者：

FINN, R

CHEUNG, NKV

DIVGI, C

STGERMAIN, J

GRAHAM, M

PENTLOW, K

LARSON, SM

机构：

[1] MEM SLOAN KETTERING CANC CTR,DEPT MED PHYS,NEW YORK,NY 10021

[2] MEM SLOAN KETTERING CANC CTR,DEPT PEDIAT,NEW YORK,NY 10021

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1991年 / 18卷 / 01期

关键词：

D O I：

10.1016/0883-2897(91)90040-R

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Many factors, both physical and chemical, affect the radiolabeling of a chemical compound. These factors add a new dimension of complexity when the labeling of monoclonal antibodies is attempted with short-lived, positron emitting radionuclides. A lack of appreciation for the unique chemical separations associated with the radionuclide incorporated into the synthetic precursor can often lead to unexpected or non-reproducible results.

引用

页码：9 / 13

页数：5

共 32 条

[1] RADIOISOTOPIC LABELING BY SURFACE CATALYSIS .3. RADIOIODINATIONS OF ORGANIC-MOLECULES ON SILICA-GEL SURFACES [J].