ORAL ERYTHROMYCIN PROPHYLAXIS AGAINST STREPTOCOCCUS-PYOGENES INFECTION IN PENICILLIN-ALLERGIC MILITARY RECRUITS - A RANDOMIZED CLINICAL-TRIAL

被引:17
作者
FUJIKAWA, J
STRUEWING, JP
HYAMS, KC
KAPLAN, EL
TUPPONCE, AK
GRAY, GC
机构
[1] UNIV MARYLAND,SCH MED,DEPT EPIDEMIOL & PREVENT MED,BALTIMORE,MD 21201
[2] USN,MED RES INST,DIV EPIDEMIOL,BETHESDA,MD 20814
[3] USN,ENVIRONM & PREVENT MED UNIT 5,DEPT EPIDEMIOL,SAN DIEGO,CA 92132
[4] USN,ENVIRONM & PREVENT MED UNIT 5,DEPT MICROBIOL,SAN DIEGO,CA 92132
[5] UNIV MINNESOTA,DEPT PEDIAT,WHO,COLLABORATING CTR REFERENCE & RES STREPTOCOCCI,MINNEAPOLIS,MN 55455
关键词
D O I
10.1093/infdis/166.1.162
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Historically, military recruits have required benzathine penicillin G to prevent epidemics of Streptococcus pyogenes. In this randomized clinical trial, low-dose oral erythromycin was evaluated as an alternative for prophylaxis against group A beta-hemolytic streptococci in penicillin-allergic recruits. US Marine Corps recruits (186) reporting penicillin allergy were randomly given either oral erythromycin (250 mg twice a day) or a vitamin (one tablet daily) for 60 days. Evidence of infection was defined as a two-dilution rise in anti-streptolysin O titer. The erythromycin group had a significantly lower risk of S. pyogenes infection than did the vitamin group (relative risk 0.44; 95% confidence interval, 0.22-0.89). There was no significant difference among the treatment groups in isolation of group A beta-hemolytic streptococci from throat cultures. Low-dose oral erythromycin appears as effective as benzanthine penicillin G in preventing S. pyogenes infection.
引用
收藏
页码:162 / 165
页数:4
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