SUSTAINED 5-HYDROXYTRYPTAMINE RELEASE-INHIBITORY AND ANXIOLYTIC-LIKE ACTION OF THE PARTIAL 5-HT(1A) RECEPTOR AGONIST, BUSPIRONE, AFTER PROLONGED CHRONIC ADMINISTRATION

被引:25
作者
SODERPALM, B [1 ]
LUNDIN, B [1 ]
HJORTH, S [1 ]
机构
[1] UNIV GOTEBORG, DEPT PHARMACOL, MED AREGATAN 7, S-41390 GOTHENBURG, SWEDEN
关键词
ANXIETY; BUSPIRONE; CHRONIC TREATMENT; 5-HT; (5-HYDROXYTRYPTAMINE; SEROTONIN); 5-HT RELEASE; 5-HT(1A) RECEPTORS; MICRODIALYSIS (IN-VIVO); (RAT);
D O I
10.1016/0014-2999(93)90977-P
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The effect of prolonged administration of high doses of buspirone on its 5-hydroxytryptamine (5-HT) release-inhibitory and anxiolytic-like properties was investigated. The 5-HT release-inhibitory effect of a challenge dose of buspirone (0.5 mg/kg, s.c.) was identical in rats chronically treated with vehicle or buspirone (10 mg/kg, b.i.d. for 10 weeks), as estimated by in vivo microdialysis in the ventral hippocampus. In the same set of animals there was a significant anxiolytic-like effect in the elevated plus-maze after 5 weeks of treatment with buspirone. The results indicate that the functional capacity of 5-HT release-controlling 5-HT1A autoreceptors is retained upon chronic administration of buspirone, and that this effect may well be associated with the anxiolytic-like action of the compound.
引用
收藏
页码:69 / 73
页数:5
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