INCREASED LEVELS OF TUMOR-NECROSIS-FACTOR AND INTERLEUKIN-1 IN BRONCHOALVEOLAR LAVAGE FLUIDS FROM PIGS INFECTED WITH MYCOPLASMA-HYOPNEUMONIAE

被引：87

作者：

ASAI, T ^{[1
]}

OKADA, M ^{[1
]}

ONO, M ^{[1
]}

IRISAWA, T ^{[1
]}

MORI, Y ^{[1
]}

YOKOMIZO, Y ^{[1
]}

SATO, S ^{[1
]}

机构：

[1] NATL INST ANIM HLTH,TSUKUBA,IBARAKI 305,JAPAN

来源：

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 1993年 / 38卷 / 3-4期

关键词：

D O I：

10.1016/0165-2427(93)90085-I

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We examined the levels of tumor necrosis factor (TNF)-alpha and interleukin-1 (IL-1) in bronchoalveolar lavage fluids (BALF) from pigs experimentally infected with Mycoplasma hyopneumoniae using biological assays with WEHI-164 cells and D10.G4.1 cells, respectively. Increased TNF-alpha and IL-1 in BALF were found in infected pigs with gross and/or microscopic lesions. A time-course study suggested TNF-alpha and IL-1 to be persistently elevated in infected pigs. Their presence in BALF would thus appear to be associated with the development of pneumonic lesions in M. hyopneumoniae infected pigs.

引用

页码：253 / 260

页数：8

共 22 条

[1] ENHANCEMENT OF CYTOTOXICITY OF ACTIVE MACROPHAGES BY MYCOPLASMA - ROLE OF MYCOPLASMA-ASSOCIATED INDUCTION OF TUMOR NECROSIS FACTOR-ALPHA (TNF-ALPHA) IN MACROPHAGES [J].