HIV-1 RECOMBINANT GP160 VACCINE-INDUCED ANTIBODIES IN SERUM AND SALIVA

被引：14

作者：

GORSE, GJ

ROGERS, JH

PERRY, JE

NEWMAN, FK

FREY, SE

PATEL, GB

BELSHE, RB

SCHWARTZ, DH

CLEMENTS, ML

KEEFER, M

DOLIN, R

MCELRATH, J

COREY, L

GRAHAM, BS

WRIGHT, PF

STABLEIN, DM

MATTHEWS, TJ

BOLOGNESI, D

MESTECKY, J

WALKER, MC

FAST, PE

机构：

[1] DEPT VET AFFAIRS MED CTR, ST LOUIS, MO USA

[2] JOHNS HOPKINS UNIV, BALTIMORE, MD 21218 USA

[3] UNIV ROCHESTER, ROCHESTER, NY 14627 USA

[4] GEORGE WASHINGTON UNIV, WASHINGTON, DC USA

[5] VANDERBILT UNIV, NASHVILLE, TN 37240 USA

[6] EMMES CORP, POTOMAC, MD USA

[7] DUKE UNIV, DURHAM, NC 27706 USA

[8] UNIV ALABAMA, BIRMINGHAM, AL USA

[9] NIAID, DIV AIDS, BETHESDA, MD 20892 USA

来源：

VACCINE | 1995年 / 13卷 / 02期

关键词：

HIV-1; VACCINE; SALIVA ANTIBODIES; IMMUNOGENICITY; ANTI-ENVELOPE GLYCOPROTEIN;

D O I：

10.1016/0264-410X(95)93138-Y

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

As part of a phase I safety and immunogenicity trial of a vaccinia-expressed HIV-1 recombinant gp160 (rgp160) candidate vaccine, we measured serum and saliva antibody responses in low risk, uninfected volunteers. Six healthy adult volunteers received 50 mu g doses of rgp160 vaccine adjuvanted in alum and deoxycholate at months 0, 1, 6, and 12. A 200 mu g rgp160 immunization was given to four volunteers at 18 months. The vaccine induced anti-envelope glycoprotein IgG and IgA serum antibodies in all six volunteers. Saliva antibodies to envelope glycoprotein appeared in some volunteers at certain timepoints. Three volunteers appeared to transiently develop vaccine-induced secretory IgA antibody to envelope glycoprotein in whole saliva.

引用

页码：209 / 214

页数：6

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