Estrogen Intake and Copper Depositions: Implications for Alzheimer's Disease?

被引：21

作者：

Amtage, Florian ^{[1
]}

Birnbaum, Dzelila ^{[4
]}

Reinhard, Thomas ^{[4
]}

Niesen, Wolf-Dirk ^{[1
]}

Weiller, Cornelius ^{[1
]}

Mader, Irina ^{[2
]}

Meyer, Philipp T. ^{[3
]}

Rijntjes, Michel ^{[1
]}

机构：

[1] Univ Med Ctr Freiburg, Dept Neurol, Breisacherstr 64, DE-79106 Freiburg, Germany

[2] Univ Med Ctr Freiburg, Dept Neuroradiol, Freiburg, Germany

[3] Univ Med Ctr Freiburg, Dept Nucl Med, Freiburg, Germany

[4] Univ Eye Hosp Freiburg, Freiburg, Germany

来源：

CASE REPORTS IN NEUROLOGY | 2014年 / 6卷 / 02期

关键词：

C-11] PIB PET; Alzheimer's disease; Ceruloplasmin; Copper; Estrogen;

D O I：

10.1159/000363688

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We present a patient with chronic postmenopausal estrogen intake with presence of Kayser-Fleischer ring in the cornea and Alzheimer's disease and discuss the pathophysiological mechanisms of estrogen intake and copper accumulation in various tissues, including the central nervous system. Sonography was compatible with copper accumulation in the basal ganglia, but the patient showed no clinical signs of Wilson's disease. Magnetic resonance imaging and positron emission tomography revealed a typical pattern for Alzheimer's disease. We propose increased copper levels as a direct effect of estrogen intake due to an augmented ATP7A-mRNA in the intestine. Moreover, we discuss the impact of elevated free serum copper on accompanying Alzheimer's disease, knowing that copper plays a crucial role in the formation of amyloid plaques and tau aggregation. This might offer a partial explanation for the observation that postmenopausal estrogen therapy is associated with a higher risk of mild cognitive impairment and Alzheimer's disease. (C) 2014 S. Karger AG, Basel

引用

页码：181 / 187

页数：7

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