A SIMPLE-MODEL FOR MULTIION PERMEATION - SINGLE-VACANCY CONDUCTION IN A SIMPLE PORE MODEL

被引：49

作者：

SCHUMAKER, MF

MACKINNON, R

机构：

[1] BRANDEIS UNIV,DEPT CHEM,WALTHAM,MA 02254

[2] HARVARD UNIV,SCH MED,DEPT CELLULAR & MOLEC PHYSIOL,BOSTON,MA 02115

来源：

BIOPHYSICAL JOURNAL | 1990年 / 58卷 / 04期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0006-3495(90)82442-5

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Recent experimental evidence suggests that certain membrane channels operate in a nearly ion-saturated state. We therefore consider a "single-vacancy" model of ion permeation: if a channel has n conducting sites, it will contain either n or n-1 ions. Simple analytical expressions for the current, conductance, and reversal potential under bi-ionic conditions are derived. The results are compared with those of single ion models and recent experiments on Ca2(+)-activated K+ channels. © 1990, The Biophysical Society. All rights reserved.

引用

页码：975 / 984

页数：10

共 29 条

[1] NON-SELECTIVE CONDUCTANCE IN CALCIUM CHANNELS OF FROG-MUSCLE - CALCIUM SELECTIVITY IN A SINGLE-FILE PORE [J].