EXTRAMAMMARY PAGETS-DISEASE - COMPARATIVE HISTOPATHOLOGIC STUDIES OF INTRADUCTAL CARCINOMA OF THE BREAST AND APOCRINE ADENOCARCINOMA

被引:52
作者
URABE, A
MATSUKUMA, A
SHIMIZU, N
NISHIMURA, M
WADA, H
HORI, Y
机构
[1] KYUSHU UNIV, FAC MED, DEPT PATHOL, HIGASHI KU, FUKUOKA 812, JAPAN
[2] KYUSHU UNIV, MED INST BIOREGULAT, DEPT DERMATOL, FUKUOKA 812, JAPAN
关键词
D O I
10.1111/j.1600-0560.1990.tb00099.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
We examined 32 cases (38 lesions) of extramammary Paget's disease (EMPD) in relation to comparative studies on intraductal carcinoma of the breast (ductal carcinoma in situ, DCIS) and apocrine adenocarcinoma (AAC). Lesions included scrotum (18 lesions), vulva (8), axilla (6), groin (3), penis (2) and chest wall (1), and the distribution was compatible with that of apocrine or supernumerary mammary glands. Histologically, extra‐mammary Paget's and DCIS cells exhibited a large amount of a pale‐stained cytoplasm. The cytoplasm of AAC cells frequently contained granules, was eosinophilic and differed from that of Paget's or DCIS cells. Immunohistochemical studies revealed positive reactions for polyclonal and monoclonal antibodies to carcinoembryonic antigen in all EMPD and most DCIS, but not in AAC. Recent studies have shown that extramammary Paget's cells exhibit characteristics of glandular epithelial cells and that most cases of EMPD are not accompanied by an underlying carcinoma. The results obtained in this study, coupled with data on the frequency of the supernumerary breasts, lead to the speculation that extramammary Paget's cells originate from ectopic mammary glands or from pluripotential germinative cells in the epidermis, capable of differentiating toward the mammary glands. Copyright © 1990, Wiley Blackwell. All rights reserved
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页码:257 / 265
页数:9
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