IRON ACCUMULATION IN THE SUBSTANTIA-NIGRA OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP)-INDUCED HEMIPARKINSONIAN MONKEYS

被引：112

作者：

MOCHIZUKI, H ^{[1
]}

IMAI, H ^{[1
]}

ENDO, K ^{[1
]}

YOKOMIZO, K ^{[1
]}

MURATA, Y ^{[1
]}

HATTORI, N ^{[1
]}

MIZUNO, Y ^{[1
]}

机构：

[1] JUNTENDO UNIV, SCH MED, DIV PATHOL, CENT LAB MED SCI, TOKYO 113, JAPAN

来源：

NEUROSCIENCE LETTERS | 1994年 / 168卷 / 1-2期

关键词：

IRON; MPTP; MONKEY; PERLS STAIN; PARKINSONS DISEASE;

D O I：

10.1016/0304-3940(94)90462-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The mechanism of abnormal iron accumulation in the substantia nigra (SN) pars compacta of patients with Parkinson's disease (PD) is unknown. To explore this question, we made a hemiparkinsonism model in monkeys by injecting 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) into the caudate or putamen on one side, and compared iron content in the SN and other basal ganglia structures by histochemistry. The injected side, especially the SN pars compacta, showed a marked increase in iron staining. Our study indicates that an injury to the nigrostriatal system by MPTP injection can induce iron accumulation in the SN.

引用

页码：251 / 253

页数：3

共 18 条

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