ISOLATION AND CHARACTERIZATION OF A TRISIALYLLACTOSYLCERAMIDE, GT3, CONTAINING AN O-ACETYLATED SIALIC-ACID IN COD FISH BRAIN

被引：22

作者：

WAKI, H

MURATA, A

KON, K

MARUYAMA, K

KIMURA, S

OGURA, H

ANDO, S

机构：

[1] TAIYO FISHERY CO LTD,CENT RES INST,TSUKUBA,IBARAKI 30042,JAPAN

[2] KITASATO UNIV,FAC PHARMACEUT SCI,ALLERGY,TOKYO 108,JAPAN

来源：

JOURNAL OF BIOCHEMISTRY | 1993年 / 113卷 / 04期

关键词：

D O I：

10.1093/oxfordjournals.jbchem.a124073

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An O-acetylated ganglioside that generated a trisialyllactosylceramide or GT3 by base treatment was found for the first time in cod fish brain. This ganglioside was isolated by high-performance liquid chromatography, and characterized by fast atom bombardment mass spectrometry, and proton nuclear magnetic resonance spectroscopy in addition to chemical analysis. The structure was identified as a modified GT3 in which the external sialic acid is O-acetylated at the C-9 position. The chemical structure is as follows: II3(9-O-Ac-NeuAc2-8NeuAc2-8NeuAc2-3)Lac Cer.

引用

页码：502 / 507

页数：6

共 36 条

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ANDO S, 1983, NEUROCHEM INT, V5, P507, DOI 10.1016/0197-0186(83)90043-8

[2] ISOLATION AND CHARACTERIZATION OF GANGLIOSIDE 9-O-ACETYL-GD3 FROM BOVINE BUTTERMILK [J].