GENOMIC ORGANIZATION AND CHROMOSOMAL LOCATION OF THE MOUSE TYPE-I BMP-2/4 RECEPTOR

被引：36

作者：

MISHINA, Y

SUZUKI, A

GILBERT, DJ

COPELAND, NG

JENKINS, NA

UENO, N

BEHRINGER, RR

机构：

[1] UNIV TEXAS, MD ANDERSON CANC CTR, DEPT MOLEC GENET, HOUSTON, TX 77030 USA

[2] HOKKAIDO UNIV, FAC PHARMACEUT SCI, SAPPORO, HOKKAIDO 060, JAPAN

[3] NCI, FREDERICK CANC RES & DEV CTR, ABL BASIC RES PROGRAM, MAMMALIAN GENET LAB, FREDERICK, MD 21702 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 206卷 / 01期

关键词：

D O I：

10.1006/bbrc.1995.1043

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have characterized the structure of a mouse bone morphogenetic protein (BMP) type I receptor gene that can bind both BMP-2 and BMP-4. The mouse BMP-2/4 receptor gene is encoded by 11 exons and spans approximately 38-kb. Most of the intron/exon boundaries are not conserved compared to the kinase domain of the related, activin type II receptor. In addition, whereas the activin type II receptor gene contains large introns (>40 kb), the largest intron of the BMP-2/4 receptor gene is only 6.4-kb. The BMP-2/4 receptor gene (Bmpr) was mapped to mouse chromosome 14. Bmpr is closely linked to Rbp3 in the region containing pugnose, a mutation that alters bone development. Knowledge of the genomic structure of Bmpr provides important information to create Bmpr-deficient mice. (C) 1995 Academic Press, Inc.

引用

页码：310 / 317

页数：8

共 34 条

[1] MESODERMAL INDUCTION IN EARLY AMPHIBIAN EMBRYOS BY ACTIVIN-A (ERYTHROID-DIFFERENTIATION FACTOR) [J].