SEQUENCE AND EXPRESSION OF A 90-KILODALTON HEAT-SHOCK PROTEIN FAMILY MEMBER OF THEILERIA-PARVA

被引：17

作者：

GERHARDS, J

EBEL, T

DOBBELAERE, DDAE

MORZARIA, SP

MUSOKE, AJ

WILLIAMS, RO

LIPP, J

机构：

[1] KERNFORSCHUNGSZENTRUM KARLSRUHE GMBH, INST GENET, KARLSRUHE, GERMANY

[2] UNIV BERN, INST ANIM PATHOL, BERN, SWITZERLAND

[3] INT LAB RES ANIM DIS, NAIROBI, KENYA

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 1994年 / 68卷 / 02期

关键词：

THEILERIA PARVA; HEAT-SHOCK PROTEIN90; STAGE-SPECIFIC EXPRESSION; SUBCELLULAR LOCALIZATION;

D O I：

10.1016/0166-6851(94)90168-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A Theileria parva specific full-length cDNA clone, T7, which encodes a protein with more than 60% homology to heat shock protein 90 (hsp90) of other organisms, has been identified. T7 appears to be a single copy gene. The gene is expressed as a protein of 87 kDa in both the sporozoite and schizont stages of T. parva. The protein was not found in the piroplasm stage, although the corresponding transcript was detected, suggesting post-transcriptional regulation of the gene. In the schizont stage the T7 protein is upregulated upon heat shock and localized in the cytoplasm.

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页码：235 / 246

页数：12

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