IMMUNOLOGICAL CHARACTERIZATION OF CHILDREN VERTICALLY INFECTED WITH HUMAN-IMMUNODEFICIENCY-VIRUS, WITH SLOW OR RAPID DISEASE PROGRESSION

被引:59
作者
VIGANO, A
PRINCIPI, N
VILLA, ML
RIVA, C
CRUPI, L
TRABATTONI, D
SHEARER, GM
CLERICI, M
机构
[1] UNIV MILAN, CATTEDRA IMMUNOL, I-20133 MILAN, ITALY
[2] UNIV MILAN, MALATTIE INFETT CLIN, MILAN, ITALY
[3] NCI, EXPTL IMMUNOL BRANCH, BETHESDA, MD 20892 USA
[4] L SACCO HOSP VIALBA, CATTEDRA PEDIAT 4, MILAN, ITALY
关键词
D O I
10.1016/S0022-3476(95)70450-7
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Cytokine production of unstimulated and mitogen-stimulated peripheral blood mononuclear cells of 31 children vertically infected with human immunodeficiency virus type 1 (HIV) and with different patterns of disease progression was evaluated to establish possible correlations between the immunologic and the clinical findings, Production of interferon gamma and interleukin-2 (type 1 cytokines), and of interleukin-4 and interleukin-10 (type 2 cytokines), was analyzed in seven symptom-free patients (Centers for Disease Control and Prevention class P-1B), 10 patients with mild symptoms (class P-2A), and 14 patients with severe symptoms (class P-PB-F), Cytokine production was compared with that of 10 age- and sex-matched control subjects who were seronegative for HIV. The HIV-infected patients produced significantly fewer type 1 cytokines and significantly more type 2 cytokines than the uninfected control subjects, No differences in the production of interferon gamma and interleukin-2 were detected among the different clinical categories of HIV-infected patients, In contrast, interleukin-4 production was augmented in the patients with class P-2A (p <0.05) and class P-SB-F HIV infection (p <0.03), in comparison with the children with class P-1B infection, The increase in interleukin-4 production was paralleled by an increase in the number of children with hyperimmunoglobulinemia E in each of the clinical groups (0% in class P-1B; 40% in class P-2A; and 71% in class P-2 B-F infection), Similarly, interleukin-10 production was increased both in patients with class P-2A and in those with class P-2B-F infection, in comparison with the children with class P-1B disease (p <0.006 and <0.04, respectively), These data indicate (1) that vertically acquired HIV infection results in decreased production of type 1 cytokines and in increased production of type 2 cytokines, and (2) that an increased production of type 2 cytokines correlates with hyperimmuno-globulinemia E and is present in, and may be characteristic of, the symptomatic phases of childhood HIV infection.
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页码:368 / 374
页数:7
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